抗凋亡蛋白survivin在急性白血病细胞中的表达及临床意义

目的 :观察 survivin在急性白血病患者骨髓细胞中的表达 ,并分析其与预后的关系。方法 :SABC免疫组化法检测survivin在初发急性白血病患者和非肿瘤患者骨髓细胞中的表达 ,分析急性白血病患者阳性表达和阴性表达者间完全缓解率(CR)的差别。结果 :survivin在急性白血病患者骨髓细胞中的表达明显高于正常对照者 (P <0 .0 1) ,且阳性表达患者的完全缓解率低于阴性表达者 (P <0 .0 5 )。结论 :survivin的阳性表达可能是白血病细胞对药物不敏感的原因之一 ,可作为判断白血病患者预后的指标之一

The expression of survivin in acute leukemia cells and its clinical significance

Objective:To investigate the expression of survivin in acute leukemia bone marrow cells,and analyze the relationship between the expression of survivin and the clinical significance. Methods: By using the immunohistochemical technique we detected the expression of survivin in the untreated acute leukemia patient's cells and the normal bone marrow cells,and analyzed the difference of CR rate between the patients with positive effect and negative effect. Results: The expression of survivin in acute leukemia bone marrow cells were significantly higher than that in the normal bone marrow cells(P<0.01).The CR rate of the patients with negative expression was higher than that of the patients with positive expression(P<0.05).Conclusion:It is possible that the expression of survivin influences the clinical effect, which might have clinical significance in predicting the prognosis in acute leukemia.