| 糖尿病大鼠海马神经元电压门控钠离子通道的研究 |
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| 引用本文： | 陈伟燕,郑小伟.糖尿病大鼠海马神经元电压门控钠离子通道的研究[J].浙江中医药大学学报,2008,32(1):34-35. |
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| 作者姓名： | 陈伟燕 郑小伟 |
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| 作者单位： | 浙江中医药大学基础医学院,杭州,310053 |
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| 基金项目： | 浙江省教育厅科研基金资助(No:20050829)~~ |
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| 摘 要： | 目的]研究糖尿病大鼠海马神经元电压门控钠离子通道的变化,探讨糖尿病神经系统的退化机制。方法]用全细胞膜片钳技术记录糖尿病大鼠海马神经元Na 电流的变化。结果]糖尿病大鼠海马神经元电压门控钠离子通道的Na 电流I-V曲线明显上移。结论]糖尿病大鼠海马神经元钠离子通道Na 电流水平下降。
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| 关 键 词： | 糖尿病 海马神经元 钠离子通道 电压门控 实验研究 |
| 文章编号： | 1005-5509(2008)01-0034-02 |
| 修稿时间： | 2007年9月25日 |
The Study of Voltage Gated Sudium Channel of Hippocampal Neurons in Diabetic Rat Brain |
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| Chen Weiyan,Zheng Xiaowei.The Study of Voltage Gated Sudium Channel of Hippocampal Neurons in Diabetic Rat Brain[J].Journal of Zhejiang University of Traditional Chinese Medicine,2008,32(1):34-35. |
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| Authors: | Chen Weiyan Zheng Xiaowei |
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| Abstract: | Objective] To study the change of voltage gated sodium channel of diabetic rats' hippocampal neurons and explore the degenerating mechanism of diabetes's nerve system.Methods] Sodium currents of diabetic rats' hippocampal neurons were registered by using the whole-cell patch-clamp technique.Results] The I-V curve of sodium currents of voltage gated sodium channel of diabetic rats' hippocampal neurons was shifted to the much higher level.Conclusion] Sodium currents of voltage gated sodium channel of diabetic rats' hippocampal neurons decreased. |
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| Keywords: | diabetes hippocampal neuron sodium channel electric-pressure controled door experimental study |
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