Eosinophilic leukemia associated with t(2;5)(p23;q31) |
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Authors: | Lepretre Stéphane Jardin Fabrice Buchonnet Gérard Lenain Pascal Stamatoullas Aspasia Kupfer Ingrid Courville Philippe Callat Marie Paule Contentin Nathalie Bastard Christian Tilly Hervé |
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Affiliation: | Department of Haematology, Centre Henri Becquerel, Rue d'Amiens, 76038 Rouen Cedex, France. slepretre@rouen.fnclcc.fr |
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Abstract: | Chromosomal aberrations have been reported in most malignant hematopoietic disorders such as acute or chronic myeloid leukemia, acute lymphoid leukemia, and myelodysplastic syndromes. Eosinophilic leukemia is a rare hematologic malignancy difficult to distinguish from other forms of idiopathic hypereosinophilic syndrome, so that the diagnosis is often made by exclusion, unless cytogenetic abnormalities can be demonstrated in bone marrow cells. We describe a patient with eosinophilic leukemia whose cytogenetic study shows a t(2;5)(p23;q31). Initial data could suggest a clonal eosinophilia, with an hepatosplenomegaly, severe pancytopenia, and a high level of blood and medullar eosinophilia. |
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