肿瘤特异生长因子检测在肿瘤诊断与疗效观察中的应用

目的　研究肿瘤特异生长因子检测在肿瘤诊断及治疗效果观察中应用的意义。方法　采用比色法对 2 0 9例恶性肿瘤患者 ,33例正常人 ,15例良性瘤患者及部分恶性肿瘤患者治疗后血清肿瘤特异生长因子 (TumorSpecificGrowthFacter,TSGF)进行检测分析。结果　恶性肿瘤患者血清TSGF浓度明显高于正常对照组和良性肿瘤患者 ,并且恶性肿瘤患者治疗后血清TSGF浓度明显比治疗前低。血清TSGF测定对恶性肿瘤诊断的敏感性为 80 9% ,特异性为 93 2 %。结论　血清TSGF检测对恶性肿瘤的早期诊断 ,病情观测 ,疗效观察及预后有重要意义。

Application of Determination of Serum TSGF to Tumor Diagnosis and Observation of Curative Effect

Objective Study the significance of determination of serum TSGF in tumor diagnosis and observation of curative effect.Methods We have measured serum TSGF level with colorimetry in 33 normal people, 209 malignant tumor patients, 15 carcinoid patients and some patients who were treated.Results (1)The serum TSGF level of malignant tumor patinets was significantly higher than that of normal people and carcinoid patients. The positive rate of the three groups was 80.9%, 3.0%, 6.7% respectively. (2) The serum TSGF level decreased after treatment. The sensibility and specificity were 80.9% and 93.6%.Conclusion Determination of serum TSGF concentration is helpful in early diagnosis of malignant tumor, observeation of curative effect and prognosis.