卵巢上皮性肿瘤血管生成活性的研究

探讨不同性质卵巢上皮性肿瘤的血管生成活性 ,并探讨血管生成与卵巢癌临床分期和病理分级的关系。方法　采用免疫组化LSAB法。结果　 74例卵巢上皮性肿瘤中 ,良性 16例、交界性 12例、恶性 46例。三组肿瘤中 ,其微血管密度依次升高。卵巢癌组 ,晚期卵巢癌微血管密度高于早期 ,中、低分化组卵巢癌微血管密度高于高分化组。结论　血管生成在卵巢癌的发生发展中起重要作用 ,微血管密度可作为判断卵巢肿瘤恶性度的一项指标。

Study on Angiogenesis of Epithelial Ovarian Neoplasms

Objective To approach the angiogenesis in epithelial ovarian neoplasms and the relations between angiogenesis and clinical stage or histological grading of epithelial ovarian carcinomas(EOC).Methods A total of 74 samples of epithelial ovarian neoplasm were tested by using immunohistochemical LSAB method.Results The microvessel density (MVD) in cystadenoma|borderling tumors and ovarian carcinomas was increased gradually,and MVD correlated with clinical stage and histological grading in EOC.Conclusions Angiogenesis may play a role in the genesis and development of EOC,and MVD can be used as an index to define the degree of malignancy of ovarian neoplasms.