ELFP方案与EFP方案治疗晚期胃癌84例疗效和毒性对比分析

目的　评估ELFP方案与EFP方案治疗晚期胃癌的疗效和毒副作用。方法　ELFP方案治疗 6 3例 ,其中小剂量CF组 (2 0mg/m2 )、中剂量CF组 (70mg/m2 )、大剂量CF组 (2 0 0mg/m2 )各 2 1例。EFP方案 2 1例。疗效和毒性用卡方检验。结果　EFP方案有效率 42 9% (9/ 2 1) ,CR 2例 ;ELFP方案总有效率 6 5 1% (41/ 6 3)、CR 11例 ,其中小剂量CF组有效率 6 1 9% (13/ 2 1)、CR 3例 ,中、大剂量CF组有效率均为 6 6 6 % (14 / 2 1) ,CR均为 4例。其疗效经 χ2 检验后 ,ELFP方案显著优于EFP方案 (P <0 0 2 5 ) ,但ELFP方案不同剂量CF组之间无显著性差异 (P >0 0 5 )。两方案毒性均可耐受。结论　ELFP方案是治疗晚期胃癌较有效的方案

Clinical Analysis of the Short-term Efficacy and Toxicity of the Advanced Gastric Cancer Treated with ELFP Regimen and EFP Regimen

Objective To evaluate the efficacy and toxicity of ELFP and EFP regimen in the treatment of advanced gastric cancer.Method 63 patients treated with ELFP regimen were equally divided into three groups the low-dose CF (leucovorin) group, the median-dose CF group and the high-dose CF group];21 patients were treated with EFP regimen. Results Response rates were 65.1% (41/63) and 42.9%(9/21),respectively for these two regimens. Besides, response rates were 61.9%(13/21), 66.6%(14/21) and 66.6%(14/21),separataly for these three gruops in ELFP regimen. There was notable statistical difference between ELFP regimen and EFP regimen, but no statstical difference among these three groups.Conclusion ELFP regimen is regarded as a better regimen for advanved gastric cancer.