甲基强的松龙联合格拉司琼治疗化疗引起的顽固性呕吐反应

目的　观察甲基强的松龙联合格拉司琼预防治疗化疗药物所至的顽固性呕吐反应的疗效。方法　选择前一周期化疗单用格拉司琼治疗无效的病例作为治疗对象 ,共 2 5例。本次化疗给予甲基强的松龙 (40mgiv ,d1～d5 ,每天化疗前 30分钟用 ) 格拉司琼(3mgiv .d1,d3 ,d5 ,当天化疗前 30分钟用 )联合治疗。前、后化疗方案和格拉司琼用药时间剂量相同。结果　 2 5例中有 13例 (5 3% )在 5天化疗期间达到完全无呕 ,5例 (2 0 % )达到部分无呕。毒副反应轻微。结论　甲基强的松龙是预防治疗化疗引起呕吐反应的有效药物。

The Antiemetic Efficacy of Methylprednisolone Combined with Granisetron in the Management of Obstinate Vomiting Induced by Chemotherapy

Objective This study observed the antiemetic efficacy of methylprednisolone combined with granisetron in the management of obstinate vomiting induced by chemotherapy.Methods Twenty-five patients whose granisetron alone was not responsed during pro-chemotherapy were includce in this study.All the patients received methylprednisolone 40mg intravenously(i.v.) for five days plus granisetron 3mg i.v. every other day for three times. All the dose and schedule of pro and post chemotherapy and granisetron were similar. Results In 25 patiemts, 13 patients had a complete response (52%),5 patients had a partial response (20%). No severe side effects were noted.Conclusions These data suggest that antiemetic therapy of methylprednisolone for obstinate vomiting induced by cancer chemotherapy be effective.