| 雷公藤二萜成分研究 |
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| 引用本文： | 张纬江,张若楠,潘德济,张罗修,徐光漪.雷公藤二萜成分研究[J].复旦学报(医学版),1986(4). |
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| 作者姓名： | 张纬江 张若楠 潘德济 张罗修 徐光漪 |
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| 作者单位： | 上海医科大学药学院天然药物化学
(张纬江，张若楠，潘德济)，上海医科大学药理学教研室
(张罗修)，上海医药工业研究院分析室(徐光漪) |
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| 摘 要： | 自福建产雷公藤的根皮部分离获得六个二萜成分(D_1～D_6)。又自湖北产雷公藤的根部得三个二萜成分(D_3、D_5和D_6)。根据其波谱数据和其他理化性质证明:D_1为雷公藤内酯酮,D_2为雷公藤内酯醇,D_3为雷酚内酯,D_4为雷酚酮内酯。D_5和D_6为两个新成分,其结构分别定为:-14-羟基-松香-8,11,13-三烯-3-酮和11-羟基,14-甲氧基-松香-8,11,13-三烯-3-酮。免疫学实验表明,以上二萜成分中D_1和D_2对由ConA引起的淋巴细胞增生有显著的抑制作用。
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| 关 键 词： | 雷公藤 雷公藤内酯酮 雷公藤内酯醇 雷酚内酯 雷酚酮内酯 14-羟基-松香-8 11 13-三烯-3-酮 11-羟基 14-甲氧基-松香-8 11 13-三烯-3-酮 二萜 |
STUDIES ON DITERPENOIDS FROM TRIPTERYGIUM WILFORDII |
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| ZHANG WEIJIANG,ZHANG RUONAN,PAN DEJI,ZHANG LUOXIU.STUDIES ON DITERPENOIDS FROM TRIPTERYGIUM WILFORDII[J].Fudan University Journal of Medical Sciences,1986(4). |
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| Authors: | ZHANG WEIJIANG ZHANG RUONAN PAN DEJI ZHANG LUOXIU |
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| Abstract: | Six diterpenoids(D1 to D6)were isolated from Tripterygium wilfordii collected from Fujian Province and Hubei Province. Their structures were confirmed by their physico-chemical properties and spectral data. D1 is triptonide: D2 is triptolide; D3 is triptophonolide; D4 is triptonolide. D5 and D6 are novel compounds. Their structures were proved to be 14-hydroxy-abieta-8, 11, 13-trien-3-one and 11-hydroxy, 14-methoxy-abieta-8, 11, 13-trien-3-one.Immunological experiments showed that D1 and D2 inhibit markedly the proliferations of lymph cells induced by Con A. |
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| Keywords: | Tripterygium wilfordii triptonide triptolide triptophenolide triptonolide 114-Hydroxy-abieta-8 11 13-trien-3-one 11-hydroxy 14-methoxy-abieta-8 11 13-trien-3-one diterpenoid |
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