妊娠期高血压疾病患者随机尿蛋白与血浆肌酐比值测定分析

目的检测妊娠期高血压疾病患者随机尿蛋白与血浆肌酐比值的变化,分析其在评估妊娠期高血压疾病病情严重程度中的作用。方法选择轻度子痫前期孕妇99例,重度子痫前期孕妇90例作为实验组,选择正常孕晚期孕妇100例作为对照组。检测随机尿蛋白、24h尿蛋白及血浆肌酐水平进行统计分析。结果轻度子痫前期、重度子痫前期组随机尿蛋白与血浆肌酐比值较正常孕晚期组增高,差异有统计学意义（P〈0.05）,且随病情加重,随机尿蛋白与血浆肌酐比值差异明显增加,轻度子痫前期与重度子痫前期组比较,差异有统计学意义（P〈0.01）。结论随机尿白蛋白/肌酐比值与子痫前期病情严重程度存在高度相关性,能够替代24h尿蛋白定量,更为快捷、简便地评估子痫前期病情严重程度。

Changes of radom spot albumlnuria to creatinine ratio in gestational hypertension

Objective To investigate the change of radom spot albumlnuria to creatinine ratio in gestational hypertension. Methods Radom spot albumlnuria, creatinine and 24h urine protein excretion were examined in 100 normal late- pregnancy women and 199 patients with gestational hypertensive. Results There Was a strong difference of radom spot albumlnuria to creatinine ratio between normal late-pregnancy women and patients with gestational hypertensive, There Was a strong difference of radom spot albumlnuria to creatinine ratio between in mild and severe preeclampsia. These differences wore statistically significant（P〈0.05）. Conclusion Radom spot albumlnuria to creatinine ratio may be a simple, convenient and accurate indicator of examining progression of gestational hypertensive. Radom spot albumlnuria to creatinine ratio may be used a replacement for 24h urine protein excretion in assessment of gestational hypertension.