| Expression Profile of Metastasis-associated Genes in Esophageal Squamous Cell Carcinoma |
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| 引用本文： | 李沛 凌志强 杨洪艳 黄幼田 赵明耀 郑智敏 董子明. Expression Profile of Metastasis-associated Genes in Esophageal Squamous Cell Carcinoma[J]. 华中科技大学学报(医学英德文版), 2006, 26(2): 167-171. DOI: 10.1007/BF02895806 |
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| 作者姓名： | 李沛 凌志强 杨洪艳 黄幼田 赵明耀 郑智敏 董子明 |
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| 作者单位： | Department of Pathophysiology College of Medical Sciences Zhengzhou University Zhengzhou 450052，China，Institute of Bioengineering，Zhejiang Academy of Medical Sciences，Hangzhou 310013，China，Department of Pathophysiology，College of Medical Sciences Zhengzhou University Zhengzhou 450052，China，Department of Pathophysiology，College of Medical Sciences Zhengzhou University Zhengzhou 450052，China，Department of Pathophysiology，College of Medical Sciences Zhengzhou University Zhengzhou 450052，China，Department of Pathophysiology，College of Medical Sciences Zhengzhou University Zhengzhou 450052，China，Department of Pathophysiology，College of Medical Sciences Zhengzhou University Zhengzhou 450052，China |
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| 基金项目： | This project was supported by a grant of 2004 Henan Pro-vincial Science and Technology Key Program Foundation(No .0424410109) |
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| 摘 要： | Esophageal cancer (EC) is one of the mostcommon fatal cancers in the worldwide , and ischaracterized by its high metastasis ,local lymphnode and blood metastasis at early stage , whichmay be the key factors of its recurrence and poorprognosis[1]. Thus ,better elucidation of molecularmechanism during metastasis is expected to i m-prove prevention and treat ment of EC. Many stud-ies have contributed to advance inits molecular as-pects . This li mited information based on singlegene ,however ,i…
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| 关 键 词： | 基因表达 食管鳞状细胞癌 病理机制 临床 |
| 收稿时间： | 2005-12-27 |
Expression profile of metastasis-associated genes in esophageal squamous cell carcinoma |
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| Li Pei,Ling Zhiqiang,Yong Hongyan,Huang Youtian,Zhao Mingyao,Zheng Zhimin,Dong Ziming. Expression profile of metastasis-associated genes in esophageal squamous cell carcinoma[J]. Journal of Huazhong University of Science and Technology. Medical sciences, 2006, 26(2): 167-171. DOI: 10.1007/BF02895806 |
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| Authors: | Li Pei Ling Zhiqiang Yong Hongyan Huang Youtian Zhao Mingyao Zheng Zhimin Dong Ziming |
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| Affiliation: | 1. Department of Pathophysiology , College of Medical Sciences, Zhengzhou University, Zhengzhou 450052, China
2. Institute of Bioengineering, Zhejiang Academy of Medical Sciences, Hangzhou 310013, China |
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| Abstract: | The differentially expressed genes between esophageal squamous cell carcinoma (ESCC) with or without lymphatic metastasis were investigated by gene chip, and the lymphatic metastasis-associated genes were screened out. Expression array was used to detect the mRNA from both the primary carcinoma and the corresponding esophageal epithelium in 15 cases of human ESCC. The lymphatic metastasis-associated genes were screened by bioinformatics between ESCC with or without lymphatic metastasis. The results showed that 43 (4.85 %) genes significantly differed between the ESCC with and without lymphatic metastasis (P<0.05), of which 18(2.03 %)were up-regulated and 25 (2.82 %) down-regulated. The up-regulated genes were involved in cell adhesion molecules and cell membrane receptors and the down-regulated genes were mostly cell cycle regulators and intracellular signaling molecules. It was suggested that lymphatic metastasis-associated genes were screened by gene chip, which was helpful to understand the molecular mechanism of ESCC lymphatic metastasis and lymphatic metastasis-associated genes might be used as diagnostic markers and therapeutic targets for lymphatic metastasis. |
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| Keywords: | esophageal squamous cell carcinoma gene chip lymphatic metastasis gene expression profile |
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