Gene-promoter hypermethylation as a biomarker in lung cancer |
| |
| Authors: | Belinsky Steven A |
| |
| Affiliation: | Lung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, USA. SBelinsk@lrri.org |
| |
| Abstract: | Silencing of genes by aberrant promoter hypermethylation is now recognized as a crucial component in cancer initiation and progression. Highly sensitive assays have been developed to assess gene-promoter methylation in biological fluids. The detection of methylated genes in sputum could lead to the development of a screening test to non-invasively identify early cancer in high-risk people. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
