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| c-fos，bax和p53的反义寡聚核苷酸（ASOs）对溶血磷脂酸所致的培养小鼠大脑皮层神经元凋亡的影响 | |
| 引用本文： | 郑肇青,方羡君,胥显民,李建国,乔健天. c-fos，bax和p53的反义寡聚核苷酸（ASOs）对溶血磷脂酸所致的培养小鼠大脑皮层神经元凋亡的影响[J]. 山西医科大学学报, 2009, 40(9): 778-785 |
| 作者姓名： | 郑肇青 方羡君 胥显民 李建国 乔健天 |
| 作者单位： | 1. 山西医科大学神经生物学研究室, 太原 030001;Neuroscience Group, Division of Basic Biomedical Sciences,School of Medicine,University of South Dakota,414 E.Clark St.,Vermillion,SD 57069,USA 2. Dept of Biochemistry,Virginia Commonwealth University,1101 East Marshall Street,Richmond,VA 23298,USA 3. 山西医科大学神经生物学研究室,太原,030001 |
| 基金项目： | 山西省青年科学基金资助项目 |
| 摘 要： | 溶血磷脂酸(lysophosphatidic acid,LPA)在高浓度时(>50 μmol/L)显示出对培养大脑皮层神经元致凋亡特性.本研究旨在初步分析溶血磷脂酸致凋亡过程中对相关基因表达的依赖性,在研究中结合琼脂糖电泳,HO33342染色和TUNEL技术观察c-fos,bax和p53三种反义寡聚核苷酸对溶血磷脂酸致培养大脑皮层神经元致凋亡的影响.结果显示结合c-fos, bax和p53三种反义寡聚核苷酸均表现出对溶血磷脂酸致凋亡的神经保护作用.溶血磷脂酸的致凋亡过程为c-fos,bax和p53基因依赖性,不同于b淀粉样蛋白片段31-35的致凋亡特性. |
| 关 键 词： | 溶血磷脂酸 凋亡 反义寡聚核苷酸 细胞培养 大脑皮层神经元 |
Effects of antisense oligodeoxynucleotides against c-fos,bax,and p53 mRNAs upon apoptosis induced by lysophosphatidic acid in cultured cortical neurons |
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| ZHENG Zhao-qing,FANG Xian-jun,XU Xian-min,LI Jian-guo,QIAO Jian-tian. Effects of antisense oligodeoxynucleotides against c-fos,bax,and p53 mRNAs upon apoptosis induced by lysophosphatidic acid in cultured cortical neurons[J]. Journal of Shanxi Medical University, 2009, 40(9): 778-785 | |
| Authors: | ZHENG Zhao-qing FANG Xian-jun XU Xian-min LI Jian-guo QIAO Jian-tian |
| Abstract: | three genes are indispensable for the LPA-induced apoptosis,showing a different genomic basis as compared to that for AbP31-35-induced apoptosis. |
| Keywords: | c-fos bax p53 lysophosphatidic acid apoptosis c-fos bax p53 antisense oligodeoxynucleotide cell culture cortical neurons |
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