A phase I study of a new 5HT3-receptor antagonist,BRL43694A,an agent for the prevention of chemotherapy-induced nausea and vomiting |
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Authors: | Geoffrey Falkson Adriaan J van Zyl |
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Institution: | (1) Department of Medical Oncology, University of Pretoria, Republic of South Africa |
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Abstract: | Summary In a phase I study of BRL43694A, a 5HT3-receptor antagonist, a single dose of 40 g/kg was given to 24 patients. All patients received cytostatic treatment expected to cause nausea and vomiting. During the first 24 h, 12 patients were completely protected from nausea and vomiting, 4 experienced nausea and 8 had moderate vomiting; mild headache occurred in 10 patients. No cardiovascular (including ECG) changes took place. Apart from headache, no neurological side effects occurred.Supported by a grant from the National Cancer Association of South Africa |
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