The quantitation of beta-aminoisobutyric acid in urine by mass fragmentography |
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Authors: | W E Pereira R E Summons W E Reynolds T C Rindflelsch A M Duffield |
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Institution: | Department of Genetics, Stanford University Medical School, Stanford, Calif. 94305 U.S.A. |
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Abstract: | A specific, rapid and sensitive method for the quantitation of β-aminoisobutyric acid in urine is described. The method is based on the analysis by quadrupole mass fragmentography of its N-TFA-O-n-butyl derivative using α-amino octanoic acid as an internal standard. The procedure is sensitive being able to quantitate as little as 1 ng of β-aminoisobutyric acid and is applicable to the routine analysis of this compound in biological fluids. The analysis time, exclusive of chemical derivatization, occupies about 17 minutes. |
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