CMV complications in common variable immunodeficiency |
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Authors: | Witte T Werwitzke S Schmidt R E |
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Affiliation: | Abteilung Klinische Immunologie, Medizinische Hochschule Hannover, Germany. witte.torsten@mh.hannover.de |
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Abstract: | A patient suffering from common variable immunodeficiency is described, who developed a myelitis under treatment with glucocorticosteroids. Later on, autoimmune complications had to be treated with azathioprine. An exacerbation of the myelitis, retinitis, encephalitis and colitis was observed and a cytomegalovirus infection diagnosed. This infection does not represent a typical complication of common variable immunodeficiency. A functional NK cell defect was detected that may contribute to susceptibility for cytomegalovirus infection in addition to immunosuppressive therapy. |
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