Effect of simvastatin on high density lipoprotein subfractions and apolipoproteins in Type IIa hypercholesterolemia |
| |
Authors: | David Crook Raymond Bruce Melek Worthington Dayid Mulcahy MRCP David Patterson FRCP Victor Wynn FRCP |
| |
Institution: | (1) Wynn Institute for Metabolic Research, Whittington Hospital, UK;(2) National Heart and Lung Institute, Whittington Hospital, UK;(3) Cardiac Department, Whittington Hospital, UK;(4) Wynn Institute for Metabolic Research, 21 Wellington Rd, St John's Wood, NW8 9SQ London, UK |
| |
Abstract: | Summary Changes in plasma concentrations of high density lipoproteins (HDL) and triglycerides may partly explain the ability of cholesterol-lowering drugs to decrease the incidence of coronary heart disease. We measured the response of fasting plasma lipids, lipoproteins, and apolipoproteins in 46 subjects with Type IIa hypercholesterolemia treated with simvastatin for 3 months. The initial dose of simvastatin (10 mg/day) was subsequently increased up to 40 mg/day if the plasma cholesterol concentration had not fallen below 5.2 mmol/l. Plasma concentrations of HDL cholesterol and of the apolipoproteins AI and AII were increased by simvastatin. The increase in HDL cholesterol (9%) was due to increases in both subfractions (HDL2 17%; HDL3 7%), changes that would be consistent with a beneficial effect on cardiovascular risk. Simvastatin decreased plasma triglyceride concentrations by 25%. Plasma total cholesterol concentrations fell by 35% after 3 months of treatment; this fall was proportional to the initial concentration and was due almost entirely to a 45% fall in low density lipoprotein cholesterol. In contrast, plasma concentrations of lipoprotein Lp(a) were not affected by simvastatin. |
| |
Keywords: | cholesterol hypercholesterolemia high density lipoproteins apolipoproteins simvastatin |
本文献已被 SpringerLink 等数据库收录! |
|