| 散发性乳腺癌组织中EMSY基因启动子甲基化状态观察 |
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| 引用本文： | 蒋建春,张海添.散发性乳腺癌组织中EMSY基因启动子甲基化状态观察[J].山东医药,2011,51(34):7-8. |
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| 作者姓名： | 蒋建春 张海添 |
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| 作者单位： | 广西医科大学第一附属医院,南宁,530021 |
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| 基金项目： | 广西省自然科学基金资助项目(0728146) |
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| 摘 要： | 目的观察散发性乳腺癌组织中EMSY基因启动子CpG岛甲基化的状态。方法用特异性甲基化PCR法检测66例散发性乳腺癌和32例正常乳腺组织中EMSY基因启动子区甲基化情况。结果乳腺癌组织有11例（16．7％）、正常乳腺组织有12例（37．5％）EMSY基因启动子发生甲基化，两者相比，P〈0．05。结论散发性乳腺癌组织中EMSY基因启动子区呈低甲基化状态，可能与散发性乳腺癌的发生发展有关。
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| 关 键 词： | 乳腺肿瘤 乳腺癌 EMSY基因 甲基化 |
Observation of EMSY gene promoter methylation status in sporadic breast cancer |
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| JIANG Jian-chun,ZHANG Hai-tian.Observation of EMSY gene promoter methylation status in sporadic breast cancer[J].Shandong Medical Journal,2011,51(34):7-8. |
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| Authors: | JIANG Jian-chun ZHANG Hai-tian |
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| Institution: | JIANG Jian-chun,ZHANG Hai-tian(Frist Affiliated Hospital of Guangxi Medical University,Nanning 530021,P.R.China.) |
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| Abstract: | Objective To observe the methylation status of the CpG islands in the promoter regions of EMSY gene in sporadic breast cancer.Methods Methylation-spcific PCR was used to detect the methylation status of EMSY promoter in 66 cases of breast cancer tissues and 32 cases of benign tissues.Results 11 case(16.7%) had methylation of EMSY promoter in tumor tissues and 12 cases(37.5%) had methylation of EMSY promoter in benign tissues,P<0.05.Conclusions There is hypomethylation of CpG island in the promoter of EMSY g... |
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| Keywords: | breast neoplasm breast cancer EMSY gene methylation |
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