| 金匮肾气丸对腺嘌呤致雄性不育模型大鼠精子质量与性激素含量的影响 |
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| 引用本文： | 马亮,贾敏,南亚昀,刘镘利,王宗仁,马静.金匮肾气丸对腺嘌呤致雄性不育模型大鼠精子质量与性激素含量的影响[J].山东中医药大学学报,2011(5):431-433. |
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| 作者姓名： | 马亮 贾敏 南亚昀 刘镘利 王宗仁 马静 |
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| 作者单位： | 第四军医大学西京医院中医科暨全军内科中心; |
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| 基金项目： | 国家自然科学基金资助项目(编号:3087326) |
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| 摘 要： | 目的:观察金匮肾气丸对腺嘌呤致雄性不育大鼠精子质量及性激素含量的影响。方法:30只SD大鼠随机分为空白对照组、腺嘌呤组、金匮肾气丸组。应用自动精子质量分析仪检测实验大鼠的精子质量(精子密度、活率及活动度);同时应用放射免疫法测定血清睾酮(T)、促黄体激素(LH)和促卵泡激素(FSH)的含量;透射电镜观察实验大鼠睾丸组织精子鞭毛密度,支持细胞、精原细胞、初级精母细胞等结构。结果:与腺嘌呤组比较,金匮肾气丸组大鼠肾阳虚症状显著改善,精子密度、活率及活动度明显提高(P<0.05);金匮肾气丸组大鼠血清T含量明显提高(P<0.05),LH、FSH含量降低(P<0.05);电镜下金匮肾气丸组大鼠精子数量明显增多,大鼠睾丸组织受损的支持细胞明显改善。结论:金匮肾气丸可提高腺嘌呤致不育模型大鼠的精子质量,其机制之一可能是通过提高血清中T的含量及保护受损的支持细胞这一间接作用实现的。
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| 关 键 词： | 金匮肾气丸 腺嘌呤 不育 肾阳虚 精子 睾丸 大鼠 |
Effects of Jingui Shenqi pills on sperm quality and contents of hormones in adenine-induced infertility rats |
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| MA Liang,JIA Min,NAN Ya-yun,LIU Man-li,WANG Zong-ren,MA Jing.Effects of Jingui Shenqi pills on sperm quality and contents of hormones in adenine-induced infertility rats[J].Journal of Shandong University of Traditional Chinese Medicine,2011(5):431-433. |
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| Authors: | MA Liang JIA Min NAN Ya-yun LIU Man-li WANG Zong-ren MA Jing |
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| Institution: | MA Liang,JIA Min,NAN Ya-yun,LIU Man-li,WANG Zong-ren,MA Jing(Department of Traditional Chinese Medicine of Xijing Hospital,Forth Military Medical University,Xi'an,710032,China) |
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| Abstract: | Objective:To observe the influence of Jingui Shenqi pills(JGSQP) on sperm quality and contents of hormones in adenine-induced infertility rats.Methods:Total 30 SD rats were randomly divided into control group,adenine group and JGSQP group.Sperm quality of experimental rats were detected by automatic sperm quality analyzer,and contents of testosterone(T),luteinizing hormone(LH) and follicle-stimulating hormone(FSH) were measured by radioimmunoassay.To observe testis by transmission electric microscopy.Result... |
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| Keywords: | Jingui Shenqi pills adenine infertility kidney-yang deficiency sperm testis rat |
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