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壳聚糖絮凝沉降法精制抗疲劳颗粒的研究
引用本文:高燕,林桂涛,盛华刚,张超. 壳聚糖絮凝沉降法精制抗疲劳颗粒的研究[J]. 山东中医药大学学报, 2011, 0(6): 545-547,558
作者姓名:高燕  林桂涛  盛华刚  张超
作者单位:山东中医药大学;
基金项目:国家科技重大专项重大新药创制; 山东省重大新药创制中心建设(编号:2009ZX09301-013)
摘    要:目的:优选壳聚糖精制抗疲劳颗粒的最佳纯化工艺。方法:采用正交试验考察药液浓缩程度、pH值、壳聚糖用量对壳聚糖絮凝沉降法精制抗疲劳颗粒的影响,优选出壳聚糖精制抗疲劳颗粒的最佳工艺。结果:最佳纯化工艺为药液浓度为1.0 g生药.mL-1、1 mL药液加入相当于壳聚糖2 mg的壳聚糖溶液、药液pH值不调。结论:壳聚糖澄清剂可以用于抗疲劳颗粒的纯化。

关 键 词:壳聚糖  絮凝沉降法  抗疲劳颗粒

Study on purification of anti-fatigue granule by chitosan flocculating setting method
GAO Yan,LIN Gui-tao,SHENG Hua-gang,ZHANG Chao. Study on purification of anti-fatigue granule by chitosan flocculating setting method[J]. Journal of Shandong University of Traditional Chinese Medicine, 2011, 0(6): 545-547,558
Authors:GAO Yan  LIN Gui-tao  SHENG Hua-gang  ZHANG Chao
Affiliation:GAO Yan,LIN Gui-tao,SHENG Hua-gang,ZHANG Chao(Shandong University of Traditional Chinese Medicine,Jinan 250355,China)
Abstract:Objective:To optimize the best purification process of anti-fatigue granule by the chitosan.Methods: Adopting the orthogonal design method to study the effect of three factors including the physic liquor concentrated degree,pH value and the amount of chitosan on refining the extract of anti-fatigue granule by the chitosan flocculating setting method.Optimize the optimum purification process of chitosan.Results:The optimum purification process was the mass concentration contained 1.0 g·mL-1,1 mL of liquid added is 2 mg of chitosan solution,pH remain unchanged.Conclusion:Chitosan can be used to the purification process of anti-fatigue granule.
Keywords:chitosan  flocculating setting method  anti-fatigue granule  
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