| Th1／Th2细胞模式与肿瘤相关性的探讨 |
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| 引用本文： | 王长印,李萍,董振芳,卢志明.Th1／Th2细胞模式与肿瘤相关性的探讨[J].山东医药,2011,51(31):25-26. |
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| 作者姓名： | 王长印 李萍 董振芳 卢志明 |
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| 作者单位： | 山东大学附属省立医院,济南,250021 |
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| 基金项目： | 济南市高校自主创新计划项目(200906050) |
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| 摘 要： | 目的观察Th1／Th2模式与肿瘤的相关性及细胞因子对Th1／Th2分化的影响，为肿瘤的免疫治疗提供依据。方法选择胃癌患者78例（胃癌组）和健康体检者80例（对照组），采用酶联免疫斑点法检测两组Th1、Th2、Th1／Th2水平；对照组35例行外周血单个核细胞培养并分为A、B、C组，A、B组培养过程中分别加入IL-12＋抗IL4单抗（终浓度分别为4∥L和10rag／L）、IL4＋抗γ-IFN单抗（终浓度分别为20μg／L和10mg／L），C组不干预，检测各组Th1／Th2细胞的比率。结果胃癌组中Th1明显低于、Th2明显高于对照组，Th1／Th2明显低于正常组，P均〈0．05；与C组比较，A组Th1细胞阳性率升高，Th2细胞阳性率降低，Th1／Th2值升高；B组Th1细胞阳性率降低，Th2细胞阳性率升高，Th1／Th2值降低（P〈0．05）。结论胃癌患者血清呈现TB2优势的分化状态；IL-12＋抗IL4单抗可改变此状态；此为进一步提高肿瘤的免疫治疗效果提供了理论依据。
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| 关 键 词： | 胃肿瘤 胃癌 Th1／Th2细胞模式 细胞因子 |
Investigation on the correlation between Th1/Th2 cell model and tumor |
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| WANG Chang-yin,LI Ping,DONG Zhen-fang,LU Zhi-ming.Investigation on the correlation between Th1/Th2 cell model and tumor[J].Shandong Medical Journal,2011,51(31):25-26. |
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| Authors: | WANG Chang-yin LI Ping DONG Zhen-fang LU Zhi-ming |
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| Institution: | WANG Chang-yin,LI Ping,DONG Zhen-fang,LU Zhi-ming(Provincial Hospital affiliated to Shandong University,Jinan 250021,P.R.China) |
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| Abstract: | Objective To observe the correlation between Th1/Th2 cell model and tumors,and the influence of cytokines on Th1/Th2 paradigm,so to provide basis for the immunotherapy of tumor.Methods Seventy-eight gastric cancer patients(gastric cancer group) and 80 health controls(control group),were enrolled in,enzyme-linked immunospot assay was used to measure Th1,Th2,Th1/Th2 paradigm,the peripheral blood mononuclear cells of 35 cases in control group were cultured and divide into A,B,C group,during the course of cultu... |
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| Keywords: | gastric carcinoma gastric cancer Th1/Th2 cell model cytokine |
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