| Anti-lipid Peroxidization Effect of Huangdan on Chronic Renal Failure in Rats |
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| 引用本文： | 郑坚峰,洪淑云,陈思源,张长弓,陈敬春,周顺长. Anti-lipid Peroxidization Effect of Huangdan on Chronic Renal Failure in Rats[J]. 华中科技大学学报(医学英德文版), 1997, 17(4): 221-224. DOI: 10.1007/BF02895624 |
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| 作者姓名： | 郑坚峰 洪淑云 陈思源 张长弓 陈敬春 周顺长 |
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| 作者单位： | ZHENG Jianfeng;HONG Shuyun;CHEN Siyuan;ZHANG Changgong;CHEN Jingchun;ZHOU Shunchang(Department of Traditional Chinese Medicine，Xiehe Hospital，Tongji Medical University，Wuhan 430022)( School of Pharmacology，Tongji Medical University，Wuhan 430030)( Depart |
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| 摘 要： | ThisprojectwassupportedbytheScientificFoundationofHealthDepartmentofHubeiProvinceChronicrenalfailure(CRF),characterizedbyprogressiverenaldamage,isaclinicalsyndromethathasaratherpoorprognosis.Iftheprogressiverenaldamagecanbeimpededordelayedatearlyormiddlestage,CRFmaybeprevented.Inthispaper,themodelofCRFwasestablishedin5/6nephrectomizedrats.DelayingEffectsofHuangdancapsuleonCRFintheseratswerestudied.Oxyamylitectusaldehydum(OTA)wasusedascontrol.Themechanismsoftheanti--lipidperoxidatione…
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| 收稿时间： | 1997-02-20 |
Anti-lipid peroxidization effect of Huangdan on chronic renal failure in rats |
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| Zheng Jianfeng,Hong Shuyun,Chen Siyuan,Zhang Changgong,Chen Jingchun,Zhou Shunchang. Anti-lipid peroxidization effect of Huangdan on chronic renal failure in rats[J]. Journal of Huazhong University of Science and Technology. Medical sciences, 1997, 17(4): 221-224. DOI: 10.1007/BF02895624 |
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| Authors: | Zheng Jianfeng Hong Shuyun Chen Siyuan Zhang Changgong Chen Jingchun Zhou Shunchang |
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| Affiliation: | (1) School of Pharmacology, Tongji Medical University, 430030 Wuhan;(2) Department of Pediatrics, Xiehe Hospital, Tongji Medical University, 430022 Wuhan;(3) Experimental Animal Center, Tongji Medical University, 430030 Wuhan;(4) Department of Traditional Chinese Medicine, Xiehe Hospital, Tongji Medical University, 430022 Wuhan |
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| Abstract: | The activity of superoxide dismutase(SOD) in renal cortex and erythrocytes, the level of lipid peroxidant(LPO)in plasma,renal function and morphology of leftover kidney were examined in rats.The results showed that Huangdan capsule could slow down the increase of BUN and Scr,promote the SOD activity in renal cortex and erythrocytes, reduce the level of LPO in plasma and delay the renal pathological changes in 5/6 nephrectomized rats.The mechanism of Huangdan capsule's antiperoxidant effect, its effect on the renal pathological changes and relationship between the two effects were also discussed. |
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| Keywords: | Huangdan capsule chronic renal failure superoxide dismutase lipid peroxide |
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