| 广州市2011年登革病毒流行状况及E基因进化特征分析 |
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| 引用本文： | 蒋力云,曹毅敏,许杨,景钦隆,曹庆,狄飚,杨智聪.广州市2011年登革病毒流行状况及E基因进化特征分析[J].中华流行病学杂志,2012,33(12):1273-1275. |
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| 作者姓名： | 蒋力云 曹毅敏 许杨 景钦隆 曹庆 狄飚 杨智聪 |
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| 作者单位： | 广州市疾病预防控制中心病毒免疫科, 510440;广州市疾病预防控制中心病毒免疫科, 510440;广州市疾病预防控制中心病毒免疫科, 510440;广州市疾病预防控制中心病毒免疫科, 510440;广州市疾病预防控制中心病毒免疫科, 510440;广州市疾病预防控制中心病毒免疫科, 510440;广州市疾病预防控制中心病毒免疫科, 510440 |
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| 基金项目： | 国家自然科学基金(81271880，81273139)；广州市卫生局重点项目(201 102A212006) |
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| 摘 要： | 目的 了解2011年广州市登革热的流行情况,分析新分离毒株的E基因分子特征.方法 收集2011年广州市登革热的流行病学资料和血清标本.采用荧光定量PCR检测并确定血清型,C6/36细胞进行病毒分离,测定新分离毒株的E基因序列,利用Mega 4.0软件分析.结果 2011年广州市登革热发病高峰在9-11月.在患者血清中检测出登革热病毒1、2、4型,分离出5株登革热1型毒株.在基因型上,4株属于亚洲型,1株属于美洲/非洲型.结论 广州市登革病毒与东南亚地区的毒株有较高同源性,且存在登革热暴发的潜在风险,该病毒在广州市可能已出现本地化趋势.
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| 关 键 词： | 登革病毒 E基因 流行特征 |
| 收稿时间： | 2012/5/28 0:00:00 |
| 修稿时间： | 2012/5/28 0:00:00 |
Epidemiological situation and the E gene evolution of dengue virus in Guangzhou, 2011 |
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| JIANG Li-yun,CAO Yi-min,XU Yang,JING Qin-long,CAO Qing,DI Biao and YANG Zhi-cong.Epidemiological situation and the E gene evolution of dengue virus in Guangzhou, 2011[J].Chinese Journal of Epidemiology,2012,33(12):1273-1275. |
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| Authors: | JIANG Li-yun CAO Yi-min XU Yang JING Qin-long CAO Qing DI Biao and YANG Zhi-cong |
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| Institution: | Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China;Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China;Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China;Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China;Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China;Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China;Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China |
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| Abstract: | Objective To investigate the epidemiological characteristics of Dengue and the E gene of the new isolated strains.Methods Epidemiological data and serum samples were collected.Serotypes were detected by real-time PCR and virus was isolated in C6/36.E gene of the new isolated strains were sequenced and analyzed by Mega 4.0.Results The cases of Dengue reached at the peak during September and November,with Serotype 1,2 and 4 were involved.Five strains of serotype 1 were isolated,with 4 of them fell into the clad of Asia genotype,and 1 belonged to America/Africa genotype.Conclusion The strains isolated in Guangzhou showed a high identity to the Southeast Asian strains.There seemed high risk of outbreak of Dengue in this area,However,the Dengue virus might have already been localized. |
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| Keywords: | Dengue virus E gene Epidemiological characters |
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