Erythrocyte transketolase activity in patients with chronic renal disease

B1 vitamin deficiency was studied by the erythrocyte enzyme activation test in patients with chronic uraemia. Transketolase activity was measured in the erythrocyte haemolysates of 14 patients with chronic uraemia and in 16 healthy controls in the presence of TPP and following TPP saturation. The magnitude of activity increases as a result of TPP saturation which is probably indicative of an insignificant thiamine deficiency in patients with chronic uraemia.