血浆脑利钠肽水平与高血压病患者房颤的发生相关性研究

目的 探讨在心脏收缩功能正常情况下，高血压病患者房颤的发生与血浆脑利钠肽（BNP）水平的相关性。方法 146例心脏收缩功能正常的高血压病患者以发生房颤情况分为窦律、阵发性房颤和永久性房颤三组，进行血浆BNP水平、左房室大小的横断面调查。结果 三组间年龄、血压水平、心脏超声检测左室射血分数、左室大小等能数差异无统计学意义（P〉0．05）；永久房颤组的左房内径大于实窦律组（P〈0．05），血浆BNP水平高于窦律组（P〈0．01），而阵发性房颤组血浆BNP虽高于窦律组，但差异无统计学意义（P〉0．05）。结论 心脏收缩功能正常的高血压病患者合并永久性房颤后，BNP水平明显升高，且与左房增大有关。BNP水平是否可为高血压病患者房颤的发生进行危险分层，及与房颤的相互影响机制有待进一步研究。

Study on the relation between plasma B - type natriuretic peptide and atrial fibrillation in patients with essential hypertension

Objective To investigate the difference of brain natrivretic peptide (BNP) concentration in essential hypertension patients with or without atrial fibrillation (AF).Methods 146 patients with essential hypertension and normal heart function patients were enrolled in this study.According to AF occurrence patients were divided into sinus rhythm,paroxysmal AF and persistent AF groups.Serum concentration of BNP and demographicvariables were anaiyzed.Results BNP(vs sinus rhythm group,P<0.01) and left atrial diameter (vs sinus rhythm group,P<0.05) in patients with persistent AF was significantly higher than in control group.Though also higher but with no significant difference in BNP and left atrial diameter in the paroxysmal AF group than in the control group.Conclusion The BNP plasma levels and left atrial diameter increase,and may be used to reflect the risk of AF occurrence in essential hypertension patients.