红霉素对犬幽门括约肌压力影响及其与胃动素,生长抑素的关系

为探讨红霉素对犬幽门括约肌的作用及其机理，及其与血浆胃动素，生长抑素的关系。方法采用胃压力测量仪及放射免疫法，同步监测观察了１０条犬静脉滴ＥＭ前后和使用拮抗剂后的幽门压力、血浆ＭＴＬ，ＳＳ的变化，结论：ＥＭ具有增高犬胃幽门压力的作用，其作用机理除与血浆ＭＴＬ有着密切的关系外，血浆ＳＳ也可能共同参与了其调节机制。

The effects of erythromycin on pressure in pyloric antrum and plasma motilin, somatostain content in dog

Objective: To investigate the actions of infusion erythromycin in regulating pyloric sphincter muscle function in dogs. Methods: We measured the pressure in pyloric antrum and plasma motilin and somatostatin contents in 10 dogs using a manometric recording technique and radioimmunoassay, at the same time we also examined the influence of calcium antagonist isoptin. Results: The results showed that erythromycin significantly increased basic pressure, total pressure and wave amplitude pressure, reduced hyperbaric wave intermission to increase frequency, elevated plasma motilin and somatostain level. However, atropine and isoptin reresly changed indices except for plasma somatostatin level. Conclusions: This study suggests emythromycin may increase pressure in pyloric antrum. The effect may be related to plasma motilin and somatostatin level.