Ultrastructure of neurofibrillary tangles in progressive supranuclear palsy |
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Authors: | M. Tomonaga |
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Affiliation: | (1) Department of Clinical Pathology (Neuropathology), 35-2 Sakaecho;(2) Tokyo Metropolitan Institute of Gerontology, 35-2 Sakaecho, Itabashiku, 173 Tokyo, Japan |
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Abstract: | Summary Ultrastructure of neurofibrillary tangles was investigated on the subcortical neurons of an autopsy case of progressive supranuclear palsy. The patient was a 64-year-old female and suffered from her illness for 9 years. Two kinds of ultrastructure were observed in the subcortical neurofibrillary tangles, i.e. the 150 A straight tubules and the 220 A twisted tubules. They appeared separately in each neuron and a transition between these two structures could not be remarked. Besides, a few particles with a paracrystalline hexagonal structure were observed in some subcortical neurons. |
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Keywords: | Progressive supranuclear palsy Ultrastructure of neurofibrillary tangles Hexagonal paracrystalline structure |
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