类风湿性关节炎骨侵蚀与其相关因子的临床研究

目的探讨类风湿性关节炎(RA)骨侵蚀征象与抗环瓜氨酸肽抗体(抗CCP抗体)和类风湿因子(IgM-RF)的相关性。方法回顾性分析106例类风湿性关节炎患者资料,分别对其关节骨侵蚀,血清抗CCP抗体及IgM-RF检测结果进行统计、分析。结果106例RA患者的X光片按修正的sharp评分法进行评分分组,有骨侵蚀组60例,其中抗CCP抗体阳性48例,IgM-RF阳性49例;无骨侵蚀组46例,其中抗CCP抗体阳性22例,IgM-RF阳性30例。结论RA骨侵蚀与抗CCP抗体阳性具有相关性(p<0.01),而与IgM-RF阳性无相关性(p>0.05)。

The Clinical Study of Erosion of Bone in Patients with RA and the Associated Factors

Objective To explore the diagnostic values between the erosion of bone in patients with rheumatoid arthritis(RA) with anti-cyclic citrullinated peptide antibody(anti-CCP) and rheumatoid factors(RF).MethodsThe data of 106 patients with RA were analyzed,including the erosion of bone,anti-CCP in serum and IgM-RF.Results106 patients with RA were classified into the erosive of bone group and the non-erosive group based on the erosion of bone in X-ray by modified sharp's score.48 of 60 cases with the erosion of bone were anti-CCP positive,but 49 were positive of IgM-RF.22 of 46 cases without the erosion of bone were anti-CCP positive,but 30 were positive of IgM-RF.ConclusionThe severity of erosion of bones in patients with RA was associated with the positive of anti-CCP(p<0.01),but not with positive of IgM-RF.