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| 冠心病患者血清脂氢过氧化物和NO含量的变化 | |
| 引用本文： | 黄敏珍,周玫,陈瑗,张健. 冠心病患者血清脂氢过氧化物和NO含量的变化[J]. 南方医科大学学报, 2001, 21(4): 301-302 |
| 作者姓名： | 黄敏珍 周玫 陈瑗 张健 |
| 作者单位： | 1. 第一军医大学南方医院妇产科 2. 第一军医大学生物化学教研室 3. 第一军医大学卫生处, |
| 摘 要： | 目的探讨冠心病患者体内人血清脂氢过氧化物 （ＬＯＯＨ）和ＮＯ含量变化。方法分别应用ＦＯＸ法和硝酸还原酶 一步法测定了３３名正常人和３３名冠心病患者的血清ＬＯＯＨ和ＮＯ含量。结果冠心病患者的血清ＬＯＯＨ含量为 （７．６４±３．２６）μmol/Ｌ，显著高于正常对照组（５．７８±３．２１）μmol/Ｌ（Ｐ＜０．０５）；冠心病患者血清ＮＯ含量显著低于正常对照 ［４２．５±１８．９）μmol／Ｌ和（５１.４±１７．８）μmol/Ｌ，Ｐ＜０．０５］。结论动脉粥样硬化性心脏病的发生可能与ＬＯＯＨ含量增加和ＮＯ减少有关。 |
| 关 键 词： | 冠心病 血清 脂氢过氧化物 一氧化氮 |
| 文章编号： | 1000-2588(2001)04-0301-02 |
| 修稿时间： | 2000-09-12 |
Changes of lipoperoxide and nitric oxide levels in the sera of patients with coronary heart diseases |
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| HUANG Min-zhen,ZHOU Mei,CHEN Yuan,ZHANG Jian. Changes of lipoperoxide and nitric oxide levels in the sera of patients with coronary heart diseases[J]. Journal of Southern Medical University, 2001, 21(4): 301-302 | |
| Authors: | HUANG Min-zhen ZHOU Mei CHEN Yuan ZHANG Jian |
| Abstract: | Objective To investigate the relationship between the changes in serum lipoperoxide (LOOH) and nitric oxide (NO) levels and the pathogenesis of coronary heart diseases (CHD). Methods The concentrations of LOOH in the sera of 33 healthy subjects and 33 patients with CHD were determined by ferrous oxidation in xylenol orange (FOX) assay, while those of NO by enzymatic one-step assay with nitrate reductase. Results The average serum concentration of LOOH in the patients was (7.64±3.26) μmol/L, much higher than that of healthy subjects [(5.78±3.21) μmol/L, P<0.05]. The NO level was (42.5±18.9) μmol/L in the patients and (51.4±17.8) μmol/L in the healthy subjects, showing significant difference between the 2 groups (P<0.05). Conclusion The increased LOOH and decreased NO levels in the serum might be involved in the pathogenesis of arteriosclerotic heart diseases. |
| Keywords: | coronary heart diseases serum lipoperoxide nitric oxide |
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