血栓栓塞性疾病与肺癌

目的 提高对肺癌合并血栓栓塞性疾病的认识。方法 从８０￣９０年代由病理学细胞学确诊的１０５０例肺癌中,选择２０例合并血栓栓塞性疾病的肺癌进行回顾性临床分析。结果 肺癌并发下肢深静脉止血栓形成（ＤＶＴ）１２例（１．１４％）;并发肺血栓栓塞（ＰＴＥ０８例（４例同时有ＤＶＴ）（０．７６％）,并发伴动脉栓塞的无菌性血栓性心内膜炎（ＮＢＴＥ）４例（０．３８％）,其中６例ＤＶＴ和（或）ＰＴＥ发生于肺癌确诊前２

Thrombosis diseases and lung cancer

OBJECTIVE: To increase the awareness of lung cancer complicating thrombosis disease(TD). METHODS: 20 cases of lung cancer with TD which were from 1,050 cases of lung cancer confirmed by pathology and cytology in 80's and 90's from a teaching hospital were retrospectively reviewed. RESULTS: Of the 20 cases, there were 8 cases complicated with deep venous thrombosis(DVT); 4 cases with pulmonary thromboembolism (PTE); 4 cases with DVT and PTE, and 4 cases with nonbacterial thrombotic endocarditis (NBTE). 6 cases of DVT/PTE occurred 2-6 months before detection of lung cancer, 3 cases of NBTE had brain and peripheral artery embolism 2-7 months before detection of lung cancer. The pathology of 12 cases of lung cancer with TD was adenocarcinoma. CONCLUSIONS: TD complicating lung cancer was not unusual and could be warning sign indicating occult lung cancer. Physician ought to alert to lung cancer or other cancers when facing aged healthy subjects of sudden TD under unknown origin. The most common physiologic type of lung cancer complicating TD was adenocarcinoma. Hypercoagulation state was the most important cause of TD complicating lung cancer.