Examination of thromboxane synthase as a prognostic factor and therapeutic target in non-small cell lung cancer |
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| Authors: | Mary-Clare Cathcart Kathy Gately Robert Cummins Elaine Kay Kenneth J O'Byrne Graham P Pidgeon |
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| Affiliation: | (1) Department of Surgery, Institute of Molecular Medicine, Trinity Health Sciences Centre, St. James’s Hospital, Dublin 8, Ireland;(2) Department of Clinical Medicine, Institute of Molecular Medicine, Trinity Health Sciences Centre, St. James’s Hospital, Dublin 8, Ireland;(3) Department of Pathology, Beaumont Hospital, Dublin 9, Ireland |
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| Abstract: | Background Thromboxane synthase (TXS) metabolises prostaglandin H2 into thromboxanes, which are biologically active on cancer cells. TXS over-expression has been reported in a range of cancers, and associated with a poor prognosis. TXS inhibition induces cell death in-vitro, providing a rationale for therapeutic intervention. We aimed to determine the expression profile of TXS in NSCLC and if it is prognostic and/or a survival factor in the disease. |
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