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Ascorbic acid partly antagonizes resveratrol mediated heme oxygenase-1 but not paraoxonase-1 induction in cultured hepatocytes - role of the redox-regulated transcription factor Nrf2 |
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| Authors: | Anika E Wagner Christine Boesch-Saadatmandi Dorothea Breckwoldt Charlotte Schrader Constance Schmelzer Frank D?ring Koji Hashida Osamu Hori Seiichi Matsugo Gerald Rimbach |
| Affiliation: | (1) Institute of Human Nutrition and Food Science, Christian-Albrechts-University of Kiel, Hermann-Rodewald-Str. 6, 24118 Kiel, Germany;(2) Department of Neuroanatomy, Graduate School of Medical Sciences, Kanazawa University, 920-1192 Kakuma, Kanazawa, Japan;(3) College of Science and Engineering, School of Natural System, Kanazawa University, 920-1192 Kakuma, Kanazawa, Japan |
| Abstract: | BackgroundBoth resveratrol and vitamin C (ascorbic acid) are frequently used in complementary and alternative medicine. However, little is known about the underlying mechanisms for potential health benefits of resveratrol and its interactions with ascorbic acid. |
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