阿立哌唑、齐拉西酮、利培酮治疗女性精神分裂症患者后催乳素的变化研究

目的：探讨女性精神分裂症患者在用阿立哌唑、齐拉西酮、利培酮治疗后催乳素水平变化及闭经原因分析。方法采用随机双盲对照研究，收集本院2012年7月—2013年9月首发确诊女性精神分裂症患者180例，分为阿立哌唑组、利培酮组，齐拉西酮组，每组各60例，疗程6个月，治疗前及治疗后1个月、3个月及3个月分别检测催乳素水平及闭经例数。结果利培酮组治疗后催乳素水平显著升高（P〈0.05），有多例出现闭经现象；阿立哌唑组及齐拉西酮组治疗后催乳素水平差异无统计学意义（P〉0.05），出现闭经例数比较少。结论利培酮用药的患者容易出现催乳素升高、闭经等现象，而阿立哌唑及齐拉西酮却很少出现这种情况，疗效也比较好，建议使用。

A Study on the Changes of Prolaction Levels of Female Patients with Schizophrenia after the Treatment of Aripiprazone,Ziprasidone and Risperidone

Objective To study the changes of prolaction levels of female patients with schizophrenia after the treatment of arip-iprazone, ziprasidone and risperidone and the causes of amenorrhea. Methods A double-blind randomized-controlled study was adopted. 180 cases of first-episode female schizophrenic patients diagnosed in our hospital from July, 2012 to September, 2013, were selected and they were divided into aripiprazone group and risperidone group, ziprasidone group, 60 cases in each group. They were treated for 6 months. The prolaction level and the number of cases of amenorrhea before and 1, 3, 6 months after treat-ment were detected. Results The prolactin levels of risperidone group were elevated significantly after treatment （ P〈0.05）, and there were many cases of amenorrhea; The prolactin levels had no statistically significant differences in aripiprazole group and ziprasidone group after treatment （P〉0.05）, the cases of amenorrhea were less. Conclusion Prolactin elevation, amenorrhea and other symptoms easily occur in the patients who take risperidone, but seldom occur in the patients who take aripiprazole and ziprasidone, and the efficacy of aripiprazole and ziprasidone is better, so they are recommended to use.