羟基脲联合小剂量肠溶阿司匹林治疗真性红细胞增多症的疗效及对凝血功能的影响

目的:研究羟基脲联合小剂量肠溶阿司匹林治疗真性红细胞增多症的疗效及对凝血功能的影响.方法:选取2012年1月~2014年12月在我院接受诊治的60例门诊或住院真性红细胞增多症患者作为研究对象,根据随机数表法分为对照组、观察组,各30例.给予对照组患者羟基脲治疗,给予观察组患者羟基脲联合小剂量肠溶阿司匹林治疗.比较两组患者的凝血功能指标(PT、APTT、FIB、TT)、血象指标(Hb、RBC、PLT、HCT)及疗效.结果:治疗前,两组凝血功能指标(PT、APTT、FIB、TT)差异无统计学意义;治疗后,两组患者的PT、APTT、FIB、TT水平均低于治疗前,且观察组低于对照组,差异有统计学意义;治疗前,两组Hb、RBC、PLT、HCT指标差异无统计学意义;治疗后,两组患者Hb、RBC、PLT、HCT水平均低于治疗前,且观察组低于对照组,差异有统计学意义;观察组治疗总缓解率(96.7%)高于对照组(73.3%),差异有统计学意义.结论:羟基脲联合小剂量肠溶阿司匹林能有效改善真性红细胞增多症患者凝血功能,缓解临床症状,减少出血风险.

Effect of hydroxyurea combined with low-dose enteric-coated aspirin in the treatment of polycythemia vera and its effect on coagulation

Objective To study the effect of hydroxyurea combined with low-dose enteric-coated aspirin in the treatment of polycythemia vera and its effect on coagulation.Methods 60 cases of diagnosis and treatment of outpatient or inpatient poly-cythemia patients from January2012 - December2014 in our hospital were selected as the research object.All patients were divided into control group,observation group,each group of30 cases. Patients in the control group were treated with hydroxyu-rea,and patients in the observation group were treated with hydroxyurea combined with low-dose enteric-coated aspirin. The coagulation function index(PT、APTT、FIB、TT),blood index(Hb、RBC、PLT、HCT)and curative effect of the two groups were compared and analyzed.Results There was no significant difference in coagulation function(PT,APTT,FIB,TT)between the two groups before treatment;After treatment,the levels of PT,APTT,FIB and TT in the two groups were lower than those before treatment,and the observation group was lower than the control group,the difference was statistically significant;There was no significant difference in blood index(Hb,RBC,PLT,HCT)between the two groups before treatment;The levels of Hb,RBC, PLT and HCT in the two groups were lower than those before treatment,and the difference was statistically significant;The overall remission rate(96.7%)was significantly higher in the observation group than in the control group(73.3%),the difference was statistically significant.Conclusion Hydroxyurea combined with low-dose enteric-coated aspirin can effectively improve coagulation function in patients with polycythemia vera,relieve clinical symptoms and reduce the risk of bleeding.