APN、hs-CRP、ET-1及NO在原发性高血压患者中的检测价值

目的 :探析血清脂联素(APN)、高敏C反应蛋白(hs-CRP)、内皮素1(ET-1)及一氧化氮(NO)在原发性高血压(PH)患者中的临床价值.方法 :分析2014年2月~2016年7月在我院接受诊治的98例PH患者的临床资料.另外选取我院同期接受健康体检的160例血压低于140/90mmHg者作为本次研究的对照组,并根据血压水平的高低分成正常血压组(NBP组,低于120/80mmHg,82例)和正常高值血压组(NHBP组,120~139/80~89mmHg,78例).比较三组患者的一般资料与血清APN、hs-CRP、ET-1及NO的表达水平,并相关性分析平均动脉压(MAP)、血清APN、hs-CRP、ET-1及NO,多因素Logistic回归分析PH患者MAP的影响因子.结果 :PH组患者的收缩压(SBP)、舒张压(DBP)及MAP水平显著较NBP组、NHBP组高,且NHBP组SBP、DBP及MAP水平又显著高于NBP组;三组患者其它一般资料(包括性别、年龄、BMI值等)无显著差异.PH组患者的血清hs-CRP、ET-1水平显著高于NBP组和NHBP组,而血清APN、NO水平则显著低于NBP组和NHBP组;与NBP组相比,NHBP组患者的血清APN及NP水平显著降低,血清hs-CRP与ET-1水平显著升高.血清APN、hs-CRP、ET-1、NO均是PH患者MAP的影响因子.结论 :PH患者体内血管舒缩及炎症因子平衡失调,主要表现为血清hs-CRP及ET-1水平上升,血清APN及NO水平降低,且这种失衡在NHBP患者中就已存在.

The detective value of APN,hs-CRP,ET-1 and NO in PH patients

Objective Our retrospective study was aimed toanalyze the clinical value of serum APN, hs-CRP, ET-1 and NO in patients with primary hypertension (PH). Methods Clinical data of 98 PH patients received treatment at our hospitalfrom February, 2014 to July, 2016 was retrospectivelyanalyzed.160 persons (blood pressure<140/90mmHg) checked-up at our hos-pital at the same time were chosen as the control group, dividing into NBP group (blood pressure<120/80mmHg, 82 cases) and NHBP group (blood pressure 120-139/80-89mmHg, 78 cases). The general information and the levels of serum APN, hs-CRP, ET-1 and NO in three groups were compared. The levels of MAP, serum APN, hs-CRP, ET-1 and NO were correlatively ana-lyzed. The influence factors of MAP in PH patients were Multiariably logistic regression analyzed. Results The values of SBP, DBP, and MAP in PH group were obviously higher than those in NBP group and NHBP group, and the values of SBP, DBP, and MAP in NHBP group were obviously higher than those in NBP group, and the other general information in three groups had no statistical difference. The levels of hs-CRP and ET-1 in PH group were obviously higher than those in NBP group and NHBP group, and the levels of the serum APN and NO were obviously lower than those in NBP group and NHBP group. The levels of hs-CRP and ET-1 in NHBP group were obviously higher than those in NBP group, and the levels of the serum APN and NO were obviously lower than those in NBP group. The serum APN, hs-CRP, ET-1 and NO were all the influence factors of MAP in PH patients. Conclusion The vasomotor factors and inflammatory factors in PH patients are at an imbalance, mainly reflecting in the levels of the serum hs-CRP and ET-1 increasing, the levels of the serum APN and NO decreasing, and it already exists in NHBP patients.