健脾补肾方减轻脾肾两虚证乳腺癌患者术后化疗心脏毒性及提高生活质量的临床研究

目的:探讨健脾补肾方对乳腺癌术后TEC方案化疗不良反应的影响,为健脾补肾方能更好的应用于临床提供依据.方法:依据标准,共收集60例,随机分为治疗组(健脾补肾方联合化疗组)和对照组(单纯西医化疗组),每组各30例.比较两组患者的心电图、心肌肌钙蛋白I、肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、中医证候积分、卡氏评分.结果:1)两组患者化疗后心电图、CK、CK-MB异常率比较发现,第一周期化疗前后及第二周期化疗前比较均无明显差异,无统计学意义.在第二周期化疗后心电图、CK、CK-MB异常率比较,差异有统计学意义.说明健脾补肾方可降低第二周期化疗后心电图、CK、CK-MB异常率.2)化疗后治疗组中医证候积分有效率86.67%,高于对照组有效率53.33%,差异有显著统计学意义;治疗组卡式评分有效率93.33%,高于对照组有效率53.33%,治疗组高于对照组,差异有显著统计学意义.结论:健脾补肾方应用于脾肾两虚证乳腺癌患者术后化疗后,能减轻心脏毒副反应,并提高患者的生活质量.

A Clinical Study on the Effect of Jianpi Bushen Decoction on Cardiac Toxicity and Quality of Life in Patients with Breast Cancer after Spleen and Kidney Deficiency Syndrome

Objective Discussion on the spleen and kidney party breast cancer postoperative TEC scheme chemotherapy side effects and the influence of the quality of life, for the application of spleen and kidney in order to better to provide basis for clinical.Methods According to the standard, a total of60 cases of collection, were randomly divided into treatment group (spleen kidney MDT group) and control group (western medicine chemotherapy group),30 cases in each group. To compare two groups of patients with electrocardiogram, myocardial troponin, creatine kinase (CK), creatine kinase isoenzyme (CK-MB), Chinese medicine symptom integral, carr's score.Results 1) After chemotherapy, to compare the electrocardiogram, CK, CK-MB of two groups, it was found that abnormal rate before and after the first cycle of chemotherapy and second cycle of chemotherapy before had no obvious difference, there was no statistical significance. In the second cycle of chemotherapy after comparing P less than 0.05, the difference was statistically significant. That spleen and kidney can reduce the electrocardiogram after the second cycle of chemotherapy, CK, CK-MB abnormal rate.2) after chemotherapy, the TCM syndrome integral effectiveness the treatment group,86.67%, is higher than the control group's,53.33%, there were significant difference statistically significant; The score effective rate of the treatment group was 93.33%, higher than that of the control groups which was53.33%, there were signifi-cant difference statistically significant.Conclusion Jianpi Bushen side used in spleen and kidney deficiency in patients with breast cancer after chemotherapy, can reduce cardiac toxicity and improve the quality of life of patients.