地西泮单药与联合用药治疗小儿惊厥的疗效对比研究

目的:探讨地西泮单用与联合用药治疗小儿惊厥的临床效果.方法:选取2011年1月~2015年12月在儿科收治的180例惊厥患儿进行回顾性分析,根据治疗方法分为联合组100例和单用组80例,联合组采用地西泮+苯巴比妥治疗,对照组仅采用地西泮治疗,对比两组的治疗效果.结果:治疗前,联合组和单用组的血清NSE、血清NPY水平差异无统计学意义,治疗后24h,两组患儿的血清NSE、血清NPY水平较治疗前均显著的降低,差异具有统计学意义;治疗24h后,联合组患儿的血清NSE、血清NPY水平显著的低于单用组患儿;联合组患儿的给药后的药物起效时间、惊厥停止时间显著的低于单用组患儿,差异具有统计学意义;给药后,联合组治疗显效率42.00%高于单用组的27.50%,联合组患儿治疗效果优于单用组患儿,差异具有统计学意义.结论:地西泮联合苯巴比妥用药治疗小儿惊厥效果较好,并不会增加不良反应的发生率.

A comparative study on curative effect of diazepam monotherapy and combination therapy in the treatment of infantile convulsion

Objective To investigate the clinical effect of diazepam alone and combined treatment of children with con-vulsion.Methods Selected December January 2011 to 2015 in Department of Pediatrics of 180 cases of children with infantile convulsion were retrospectively analyzed, the treatment methods are classified according to the combined group (100 cases) and the single use group (80 cases) and combined group with diazepam and phenobarbital treatment, the control group was only treated with diazepam, compared two groups of therapeutic effect.Results Before treatment, the combined group and the sin-gle differences in serum NSE and plasma NPY levels were not statistically significant,24h after treatment, two groups of serum NSE and plasma NPY levels were significantly decreased, the difference was statistically significant; after24h treatment, the combination group with serum NSE and the plasma level of NPY was significantly lower than that of single group; joint group to the anticonvulsant drug onset time, after the stop time is significantly lower than the single group, the difference was statistically significant; after administration, the combined treatment group markedly effective rate was 42% higher than that of in group 27.50%, united the treatment group has better effect than single group, the difference was statistically significant .Conclusion Good diazepam combined with phenobarbital treatment of children with convulsion effect, the incidence of adverse reactions did not increase.