低分子肝素联合阿司匹林对复发性自然流产患者血凝状态的影响

目的:探讨低分子肝素(LMWH)联合阿司匹林对复发性自然流产(RM)患者血凝状态的影响.方法:将98例血栓前状态(PTS)复发性自然流产患者随机分为两组,每组49例.对照组行口服阿司匹林肠溶片;研究组在对照组治疗的基础上行LMWH腹壁皮下注射,对比治疗前后两组患者凝血状态改善情况及母婴结局.结果:治疗后两组患者的凝血四项中PT、TT、APTT值较治疗前显著升高,研究组的提高水平显著优于对照组,差异有统计学意义;FIB、D-二聚体(D-Dimer)水平较治疗前显著降低,研究组的改善水平与对照组相比,差异有统计学意义;两组治疗后PLT水平与治疗前比较降低,差异有显著性意义,组间比较无显著性差异.结论:LMWH联合阿司匹林能显著改善RM患者的凝血状态,恢复凝血和抗凝平衡,缓解患者血栓前状态,提高妊娠活婴产率,降低流产率.

Effect of low molecular weight heparin combined with aspirin on the blood coagulation state of recurrent spontaneous abortion patients

Objective To investigate the effect of low molecular weight heparin (molecular weight heparin LMWH, low) combined with aspirin on the blood coagulation status in patients with recurrent spontaneous abortion (miscarriage recurrent, RM). Methods 98 cases of recurrent spontaneous abortion patients (prethromboticstate, PTS) were randomly divided into two groups, 49 cases in each group. The control group was treated by oral Aspirin Enteric-coated Tablets. The study group in the control group treatment based on the LMWH abdominal wall subcutaneous injection. Improvement of blood coagulation status and maternal and infant outcomes in two groups. Results After treatment, PT, TT and APTT in two groups were significantly higher than before treatment. The improvement level of the study group was significantly better than that of the control group. The difference was statistically significant. The levels of FIB and D- two polymer (D-Dimer) were significantly lower than before treatment. The improvement level of the study group was compared with that of the control group. The difference was statistically significant. After treatment, the level of PLT in the two groups was lower than that before treatment. The difference was signifi-cant. There was no significant difference between the two groups. Conclusion LMWH combined with aspirin can significantly improve the coagulation status of patients with RM, restore the balance of coagulation and anticoagulation, ease the patient's pre thrombosis state, improve the rate of pregnant women, and reduce the rate of abortion.