甲状腺、垂体激素在中重型颅脑损伤患者中的检测意义

目的:探析甲状腺激素(TH)及垂体激素水平变化在中型颅脑损伤(MHI)、重型颅脑损伤(SHI)患者病情判断及预后情况观察中的临床价值.方法:分析2010年1月~2015年12月在我院接受诊治的50例HI患者的临床资料.根据颅脑损伤(HI)病情严重程度将入选者分成MHI组(22例)和SHI组(28例).根据预后情况将入选者分成存活组(S组,40例)和死亡组(D组,10例).另外选取同期在我院接受健康体检的45例健康者作为本次研究的对照组.比较MHI组、SHI组、对照组及S组和D组患者的TH(总三碘甲腺原氨酸TT3、总甲状腺素TT4、游离三碘甲腺原氨酸FT3和游离甲状腺素FT4)、促甲状腺激素(TSH)、血清泌乳素(PRL)及促卵泡生成素(FSH)等指标的表达水平.结果:MHI组、SHI组与对照组的一般资料无显著差异.MHI组患者的TT3、FT3明显较SHI组患者高,PRL及FSH明显较SHI组低,而TT4、FT4及TSH水平无显著差异.MHI组、SHI组患者的TT3、FT3明显较对照组低,PRL及FSH明显较对照组高,而TT4、FT4及TSH水平无显著差异.S组患者的TT3、FT3、PRL及FSH水平明显优于D组,而TT4、FT4及TSH水平无显著差异.结论:HI患者的预后情况随着其病情的加重而变差,且血清TT3、FT3、PRL及FSH可作为HI患者病情判断及其预后观察的重要指标.

The detective value of TH and pituitary hormones in patients with MHI and SHI

Objective Our retrospective study was aimed to analyze the clinical value of the changes of the levels of TH and pituitary hormones in the illness evaluation and prognosis observation of MHI, SHI patients.Methods Clinical data of50 pa-tients with HI received treatment at our hospital from January,2010 to December,2015 was retrospectively analyzed. Patients included were divided into two groups according to the severity of HI patients, MHI group (22 cases) and SHI group (28 cases). Patients included were divided into two groups according to the prognosis of HI patients, survival group (S group,40 cases) and death group (D group,10 cases).45 healthy persons checked at the same time at our hospital were chosen as the control group. The levels of TH (TT3, FT3, TT4, FT4), TSH, PRL, FSH of patients on MHI group, SHI group and control group, S group and D group were respectively compared.Results The general information in MHI group, SHI group and control group had no statisti-cal difference. The levels of TT3, FT3 in MHI group were obviously higher than those in SHI group, and the levels of PRL and FSH in MHI group were obviously lower than those in SHI group, but the levels of TT4, FT4, TSH in MHI group and SHI group had no statistical difference. The levels of TT3, FT3 in MHI group, SHI group were obviously lower than those in control group, and the levels of PRL and FSH in MHI group, SHI group were obviously higher than those in control group, but the levels of TT4, FT4, TSH in MHI group, SHI group and control group had no statistical difference. The levels of TT3, FT3, PRL and FSH in S group were obviously better than those in D group, but the levels of TT4, FT4, TSH in S group and D group had no statistical difference.Conclusion The prognosis of HI patients is worse as the degree of injury is more severe. The serum TT3, FT3, PRL and FSH could be regarded as the important indexes in determining the severity and prognosis of HI patients.