四种方案治疗新生儿黄疸的疗效及对相关生化指标的影响

目的 :探讨临床四种方案治疗新生儿黄疸的疗效及对相关生化指标的影响.方法 :120例新生儿病理性黄疸患儿随机分为A组、B组、C组、D组,各组30例,A组予蓝光照射治疗,B组予蓝光照射联合茵栀黄口服液治疗,C组在B组基础上加用布拉氏酵母菌散口服,D组在B组基础上加用双歧杆菌三联活菌散口服.评定四组治疗疗效,并检测相关相关生化指标水平的差异.结果 :C组、D组临床总有效率93.33%、90.00%显著高于A组、B组60.00%、66.67%.四组治疗前各项血清胆红素、心肌酶谱及T淋巴细胞指标水平比较无统计学意义,治疗后各项血清胆红素、心肌酶谱及T淋巴细胞指标水平均显著改善,与治疗前相比有统计学意义;治疗后A组、B组、D组、C组血清总胆红素(TBIL)、直接红素(DBIL)水平依次显著降低,以C组降低最显著,各组相比有统计学意义;C组、D组乳酸脱氢酶(LDH)、肌酸激酶(CK)、肌酸激酶同功酶(CK-MB)水平显著低于A组、B组,且CD3+、CD4+、CD4+/CD8+均显著高于A组、B组.结论 :在蓝光照射、茵栀黄口服液等常规治疗基础上加用布拉氏酵母菌散或双歧杆菌三联活菌散治疗新生儿黄疸的临床疗效显著,可有效改善患儿血清胆红素及心肌酶水平,提高免疫.

Efficacy of four kinds of regimens in treating neonatal jaundice and the effect on related biochemical indexes

Objective To investigate the clinical efficacy of four kinds of regimens in treating neonatal jaundice and the ef-fect on related biochemical indicators. Methods A total of 120 cases of neonatal pathological jaundice children were randomly divided into groupA, groupB, groupC and groupD, 30 cases in each group. Group A were treated with blue-ray radiation therapy and group B were treated with blue-ray radiation therapycombined with Yinzhihuang oral liquid. Based on the treatment in group B, group C were treated with oral administration of Saccharomyces boulardii sachets and group D were additionally treated with oral administration of Bifidobacterium triple viablepowder. The therapeutic effects in four groups were evaluated, and the levels of related biochemical indexes were detected. Results The total effective rates of treatment were significantly higher in group C and group D than group A and group B (93.33% and 60.00% vs 90.00% and 66.67%). There was no significant difference in levels of serum bilirubin, myocardial enzymes and T lymphocytes among four groups. After treatment, the above levels were significantly improved. After treatment, levels of serum total bilirubin (TBIL) and direct bilirubin (DBIL) in four groups decreased significantly, and the decrease was the most significant in groupC. Levels of lactate dehydrogenase (LDH), creatine kinase (CK) and creatine ki-nase isoenzyme (CK-MB) were significantly lower in group C and group D than group A and group B, CD3+, CD4+ and CD4+/CD8+were significantly higher than group A and group B. Conclusion On the basis of blue-ray radiation therapy and Yinzhihuang oral liquid, the efficacy of Saccharomyces boulardii sachetsor Bifidobacterium triple viable powder is significant in the treatment of neonatal jaundice, which can effectively improve the levels of serum bilirubin and myocardial enzymes and improve immune.