疏血通联合神经节苷脂注射液治疗脑梗死的临床研究

目的:观察疏血通联合神经节苷脂注射液治疗脑梗死的临床效果.方法:将于我院就诊的92例脑梗死患者随机分为对照组和治疗组各46例,对照组患者给予神经节苷脂注射液,治疗组患者则给予疏血通联合神经节苷脂注射液治之,15d为疗程,连续用药2个疗程.比较两组治疗的临床有效率,评估治疗前后的神经功能缺损程度变化,检测血液流变改善情况及血清细胞因子水平变化.结果:观察组有效率93.5%与对照组73.9%相比升高显著;治疗组的NIHSS评分明显低于治疗前,且显著低于对照组;治疗组患者各血液流变指标的变化程度较对照组更显著;治疗组经治疗后血清细胞因子CRP、IL-6、Hcy水平均显著低于对照组,而NO水平则显著高于对照组.结论:疏血通联合神经节苷脂注射液协同作用治疗脑梗死疗效肯定,利于提高神经功能,其机制可能与改善血液微循环及调控细胞因子水平有一定相关性.

Clinical Research on Treating Cerebral Infarction Patients with Shuxuetong and Ganglioside Injection

Objective To investigate the clinical efficacy of treating cerebral infarction patients with shuxuetong and gan-glioside injection. Methods 92 patients were randomly divided into a control group of 46 cases and an observation group of 46cases. Patients in the control group were treated with ganglioside injection, patients in the observation group were treated with shuxuetong and ganglioside injection, 15 days for a course, 2 courses for treatment . The research was aimed at comparing the effectiveness, evaluating the patients'degree of nerve function defect, monitoring the change of hemorheology and serum levels of cytokines. Results The efficiency of patients in the observation group was 93.5%, which was higher than that of the control group 73.9%; The improvement of nerve function for the patients in the observation group was better than that of the control group after treatment, and the NIHSS scores were lower than that of the control group; The improvement of blood rheology in-dexes for the patients in the observation group was better than that of the control group after treatment; The CRP, IL-6 and Hcy levels of the patients in the observation group was lower than that of the control group after treatment, while the NO activity was higher than that of the control group. Conclusion The therapy has good effect, it is good to improve the patients'nerve function. The mechanism may be associated with regulating the levels of blood rheology indexes and serum cell factor.