Production of Monocyte Chemoattractant Protein 1 in Tuberculosis Patients |
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| Authors: | YuanGuang Lin JianHua Gong Ming Zhang Wanfen Xue and Peter F Barnes |
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| Institution: | Department of Medicine, University of Southern California School of Medicine, Los Angeles, California 900331.; Center for Pulmonary and Infectious Disease Control,2. Department of Cell Biology,4. and Department of Medicine,5. The University of Texas Health Center, Tyler, Texas 75710; and Department of Pathology, Nanjing Medical University, Nanjing, People’s Republic of China3. |
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| Abstract: | To investigate the role of monocyte chemoattractant protein 1 (MCP-1) in the immune response to Mycobacterium tuberculosis, we studied MCP-1 production in tuberculosis patients. CD14+ blood monocytes from tuberculosis patients spontaneously expressed higher levels of MCP-1 mRNA and protein than CD14+ monocytes from healthy tuberculin reactors. MCP-1 production in lymph nodes from tuberculosis patients was also markedly increased. These findings suggest that MCP-1 can contribute to the antimycobacterial inflammatory response by attracting monocytes and T lymphocytes. |
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