| 膀胱癌ras,MDR1基因表达及其相互关系的实验研究 |
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| 引用本文： | 吴长利 吴国志. 膀胱癌ras,MDR1基因表达及其相互关系的实验研究[J]. 天津医药, 1998, 26(5): 289-290 |
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| 作者姓名： | 吴长利 吴国志 |
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| 作者单位： | [1]天津市泌尿外科研究所 [2]佳木斯市中心医院 |
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| 摘 要： | 应用免疫组化技术对３２例膀胱癌ｒａｓ基因，ＭＤＲ１基因的表达及其相互关系进行了研究。结果表明：３２例膀胱癌ｒａｓ基因，ＭＤＲ１基因的阳性表达率分别为３７．５％，６２．５％，初发膀胱癌ｒａｓ基因，ＭＤＲ１基因的阳性表达率分别为３５％，５０％，而化疗后复发的膀胱癌ｒａｓ基因、ＭＤＲ１基因的阳性表达率为４１．６％、８３．３％。随着肿瘤病理分级的升高，ｒａｓ基因及ＭＤＲ１基因的阳性表达率也随之增高，结果证
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| 关 键 词： | 膀胱肿瘤 基因表达 ras基因 MDR1基因 实验研究 |
Correlation between Expression of Ras and MDR_3 Gene in Bladder Cancer Tissue |
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| Wu Changli,Wu Guozhi,Ma Tengxiang,et al Tianjin Institute of Urologic Surgery. Correlation between Expression of Ras and MDR_3 Gene in Bladder Cancer Tissue[J]. Tianjin Medical Journal, 1998, 26(5): 289-290 |
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| Authors: | Wu Changli Wu Guozhi Ma Tengxiang et al Tianjin Institute of Urologic Surgery |
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| Affiliation: | Wu Changli,Wu Guozhi,Ma Tengxiang,et al Tianjin Institute of Urologic Surgery 300211 |
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| Abstract: | The study of expression of ras and MDR1 gene with the immunohistochemical technique in 32 patients with bladder tumor revealed that the positive expression rates of ras,MDR1 gene were 37.5% and 62.5% respectively in 32 cases, 35% and 50% respectively in primary tumor, but in recurrent tumor 41.6% and 83.3% respectively,and ras, MDR1 gene expression rates increased as the pathologic grade ascended. These results indicated that the overexpression of ras,MDR1 gene was closely associated with malignant biological behavior, pathologic grade and recurrence of bladder tumor, and the expression of ras gene may activate and regulate MDR1 gene expression. |
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| Keywords: | bladder cancer gene expression immunohistochemistry |
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