| 肾上腺髓质素与肾上腺紧张素在维持性血透中的变化 |
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| 引用本文： | 张昭馥 石湘芸. 肾上腺髓质素与肾上腺紧张素在维持性血透中的变化[J]. 天津医药, 1998, 26(9): 515-518 |
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| 作者姓名： | 张昭馥 石湘芸 |
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| 作者单位： | [1]中国人民解放军海军总医院肾内科 [2]中国人民解放军海军总医院心内科 |
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| 摘 要： | 应用放免法测定３２例维持性血透患者透析前后血浆肾上腺髓质素（ＡＤＭ１３－５２）及前体肾上腺紧张素（ＡＤＭ１５３－１８５）水平。发现ＡＤＭ１３－５２较正常人明显升高（Ｐ〈０．０１），而ＡＤＭ１５３－１８５则明显下降（Ｐ〈０．０１）。前者与ＭＡＰ、血浆ＢＵＮ、ＥＴ有明显相关性，ｒ值分别为０．４９２、０．７４３、０．４９２，而后者与ＭＡＰ、ＢＵＮ、ＥＴ无相关。血液透析后ＡＤＭ１３－５２与ＡＤＭ１５３－１
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| 关 键 词： | 肾上腺髓质素 ADM 肾性高血压 血液透析 |
The Changes of ADM_(15-52) and ADM_(153-18)5 in Maintenance Hemodialysis |
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| Zhang Zhaofu,Shi Xiangyun,Zhao Yuntao,et al Navy General Hospital of PLA,Beijing. The Changes of ADM_(15-52) and ADM_(153-18)5 in Maintenance Hemodialysis[J]. Tianjin Medical Journal, 1998, 26(9): 515-518 |
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| Authors: | Zhang Zhaofu Shi Xiangyun Zhao Yuntao et al Navy General Hospital of PLA Beijing |
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| Affiliation: | Zhang Zhaofu,Shi Xiangyun,Zhao Yuntao,et al Navy General Hospital of PLA,Beijing 100037 |
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| Abstract: | The levels of ADM13-52 and ADM153-185 in 32 patients were assayed by RIA. The results showed that ADM13-52 levels were markedly higher than those of the normal subjects(P<0.01) ,but ADM153-185 levels were markedly lower(P< 0.01). There was a positive relationship between ADM153-185 and mean arterial pressure (MAP), plasma BUN and ET, but ADM153-1855 was not. After dialysis both ADM13.52 and ADM153-185 did not change markedly. Their changes had no relation with the changes of BUN,Cr,HCO3- , K ,Na , Cl- , MAP and Osm. The results showed that ADM13-52 and ADM,53.185, which were newly found vaso-active substance,adjusted circuit and BP, their misadjustment may be one of the reasons which led to renal hypertension. The acute effect of HD does not affect ADM13-52 and ADM151-185 definitely. |
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| Keywords: | adrenomedullin(ADM13-52) adrenotensiont AL)MI53.185) vaso-active polypeptide renal hypertension hemodialysis |
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