| 一氧化氮在肺感染中损伤作用机制探讨 |
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| 引用本文： | 张世国,彭立义.一氧化氮在肺感染中损伤作用机制探讨[J].天津医药,1998,26(11):653-655. |
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| 作者姓名： | 张世国 彭立义 |
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| 作者单位： | 中国人民解放军济南军区总医院检验科，中国人民解放军济南军区总医院检验科，中国人民解放军济南军区总医免疫科，中国人民解放军济南军区总医院检验科，中国人民解放军济南军区总医院 呼吸科 250031，250031，250031，250031，250031 |
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| 摘 要： | 观察４０例肺感染患者血中一气体氮（ＮＯ）及肿瘤坏死因子（ＴＮＦ）、超氧化物歧化酶（ＳＯＤ）、丙二醛（ＭＤＡ）水平变化，并与３０例正常人进行对比，同时对治疗后的１８例患者各指标的变化进行了观察。结果显示：患者血清ＮＯ及ＴＮＦ、ＭＤＡ水平较对照组显著增高（Ｐ〈０．０１），ＳＯＤ则显著降低（Ｐ〈０．０１），治疗后较治疗前血清ＮＯ、ＴＮＦ及ＭＤＡ水平显著降低（Ｐ〈０．０５），而ＳＯＤ活性则显著回升（Ｐ〈０
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| 关 键 词： | 肺炎 一氧化氮 肿瘤坏死因子 |
The Damaging Mechanism of Nitric Oxide in Patients with Pulmonary Infection |
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| Zhang Shiguo,Peng Liyi,Luo Nanping,et al General Hospital of Jinan Military,Jinan.The Damaging Mechanism of Nitric Oxide in Patients with Pulmonary Infection[J].Tianjin Medical Journal,1998,26(11):653-655. |
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| Authors: | Zhang Shiguo Peng Liyi Luo Nanping General Hospital of Jinan Military Jinan |
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| Institution: | Zhang Shiguo,Peng Liyi,Luo Nanping,et al General Hospital of Jinan Military,Jinan 250031 |
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| Abstract: | The levels of serum nitric oxide(NO), tumor necrosis factor(TNF) ,superoxide dismutase(SOD)and malondiadehyde(MDA)were studied in 40 patients with pulmonary infection,and the data were compared with 30 normal subjects. The indexes were observed further in 18 patients after treatment. The results showed that:(l)in patient group, the levels of serum NO,TNF and MDA were significantly higher and SOD was obviously lower than those in control group(F<0.01); (2)after treatment, the levels of serum NO,TNF and MDA decreased significantly(P<0.05),and SOD rised markedly(P< 0.01)than before treatment. These indicated that NO and its related indexes had important pathological roles in pulmonary infection. |
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| Keywords: | pneumonia nitric oxide tumor necrosis factor damage |
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