| 斑秃患者淋巴细胞CD54分子表达的研究 |
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| 引用本文： | 曹瑞华,刘华昌.斑秃患者淋巴细胞CD54分子表达的研究[J].天津医药,1998,26(3):142-143. |
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| 作者姓名： | 曹瑞华 刘华昌 |
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| 作者单位： | 济南军区总医院皮肤科
250031(曹瑞华，刘华昌，李冠勇，周春蕾)，济南军区总医院流式细胞研究室 250031(尹格平) |
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| 摘 要： | 为为了解淋巴细胞粘附分子与斑秃发病的关系。应用ＦＡＣＳｃａｎ流式的细胞仪，对斑秃患者外周血淋巴细胞ＣＤ５４分子的表达进行了定量研究。结果显示：１．斑秃患者的淋巴细胞ＣＤ５４表达量较对照组显著增高。２．全秃患者淋巴细胞ＣＤ５４分子表达量明显高于局限性患者。３．患者淋巴细胞ＣＤ５４分子表达与病程长短无关。提示淋巴细胞粘附分子可能在斑秃发病中起重要作用。
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| 关 键 词： | 斑秃 细胞粘着分子－1 流式细胞术 淋巴细胞 |
Expression of CD_(54) Molecule on Lymphocytes from Patients with Alopecia Areata |
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| Cao Ruihua,Liu Huachang,Li Guanyong,et al.Expression of CD_(54) Molecule on Lymphocytes from Patients with Alopecia Areata[J].Tianjin Medical Journal,1998,26(3):142-143. |
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| Authors: | Cao Ruihua Liu Huachang Li Guanyong |
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| Institution: | Cao Ruihua,Liu Huachang,Li Guanyong,et al Department of Dermatology,Jinan Military General Hospital,Jinan 250031 |
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| Abstract: | In order to understand the relationship between lymphocyte-adhesion molecule and pathogenesis of alopecia areata, expression of CD54 on lymphocytes from patients with alopecia areata were detected by using flow cytometry. The results were as follows; (1)Compared with normal subjects,increased expression of CD54 on lymphocytes from patients was observed(P<0. 001). (2)Expression of CD54 in generalized lesion group was increased compared with localized lesion group(P<0. 05). (3)There was no correlation between expression of CD54 and course of the disease. It is suggested that CD54 molecule may play an important role in the pathogenesis of alopecia areata. |
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| Keywords: | alopecia areata intercellular adhesion molecule-1 flow cytometry |
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