| 肿瘤病人外周血T细胞及其亚群和NK细胞活性变化的研究 |
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| 引用本文： | 周正任,李长荣,李晓菲,刘桂芬,于维福,赵惠远,马树俊.肿瘤病人外周血T细胞及其亚群和NK细胞活性变化的研究[J].中国免疫学杂志,1987(5). |
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| 作者姓名： | 周正任 李长荣 李晓菲 刘桂芬 于维福 赵惠远 马树俊 |
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| 作者单位： | 中国医科大学微生物学教研室，中国医科大学附属第一医院内科免疫室，中国医科大学微生物学教研室，中国医科大学微生物学教研室，中国医科大学微生物学教研室，中国医科大学微生物学教研室，北京医科大学微生物学教研室 沈阳，沈阳，沈阳，沈阳，沈阳 |
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| 摘 要： | 一般认为,T细胞和NK细胞可能是构成机体肿瘤免疫功能的重要因素。肿瘤病人外周血T细胞及其亚群和NK细胞活性的变化,国内外均有报道。但对同一肿瘤病人T细胞及其亚群和NK细胞活性变化的对比研究报道得较少。本文用OKT系列的单克隆抗体检测T细胞及其亚群,用~(51)Cr-释放试验检测NK细胞活性,对同一肿瘤病人外
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Studies on T cell,T Cell Subpopulation and Natural Cell Activities of the Peripheral Blood Lymophocytes from Patients with Tumor |
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| Zhou Zhengren,et al.Studies on T cell,T Cell Subpopulation and Natural Cell Activities of the Peripheral Blood Lymophocytes from Patients with Tumor[J].Chinese Journal of Immunology,1987(5). |
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| Authors: | Zhou Zhengren |
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| Abstract: | In this paper,we reported that T cell,T cell subpopulation and natural killer(NK)cell activities of peripheral blood lymophocytes from the Fatients with tumor weredetected with OKT monoclonal antibody and ~(51)Cr release cytotoxity test.The resultsshowed that percentage of OKT3~+,OKT4~+ cell in the peripheral blood of patients withtumor are low,OKT8~+ is high and the ratio of OKT4/OKT8 is low.The results haveproved that the ratio of OKT4/OKT8 and NK cell activities were significantly low inthe peripheral blood of patients with tumor.However,the activities have restored tonormal or near normal level in the patients after surgical operation for more that twoyears with no recurrence. Our data suggest that detecting of the ratio of OKT4/OKT8 and activities of NKcell might be valuable to the prognosis of patients with tumor. |
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| Keywords: | OKT monoclonal antibody NK activities ~(51)Cr release cytotoxity |
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