Sustained complete remission after chemobiohormonal therapy for metastatic melanoma |
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Authors: | Stein M E Bernstein Z Drumea K Zalik M Shklar Z Steiner M Haim N |
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Affiliation: | Northern Israel Oncology Center, Rambam Medical Center and Faculty of Medicine, Technion--Israel Institute of Technology, Haifa. |
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Abstract: | The combination of carmustine, cisplatin, dacarbazine, interferon, and low-dose tamoxifen is widely used in treating metastatic melanoma and was originally reported to achieve a 20% complete response rate. Among 29 patients who completed the authors' phase II study with the regimen, five (17%) achieved complete remission, and the median duration of response was 8 months (range, 2-14 months). The aim of the study was to evaluate briefly the value and toxicity of this regimen in treating metastatic malignant melanoma. |
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