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Immune Abnormalities Induced by Human Endogenous Retroviral Peptides: With Reference to the Pathogenesis of Systemic Lupus Erythematosus |
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| Authors: | Toshio Naito Hitoshi Ogasawara Hiroshi Kaneko Takashi Hishikawa Iwao Sekigawa Hiroshi Hashimoto Naoki Maruyama |
| Affiliation: | (1) Department of General Medicine, Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan;(2) Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan;(3) Department of Medicine, Juntendo University Izu-Nagaoka Hospital, Izu-Nagaoka-cho, Tagata-gun, Shizuoka, Japan;(4) Department of Molecular Pathology, Tokyo Metropolitan Institute of Gerontology, Itabashi-ku, Tokyo, Japan |
| Abstract: | P15E is a specific sequence among the envelope gene (env)-encoded transmembrane proteins of exogenous and endogenous retroviruses. A synthetic peptide (CKS-17) that shows homology to this p15E region in several species of retrovirus is known to induce immune abnormalities. In this study, we examined the effect of a synthetic peptide derived from a region of human endogenous retrovirus (HERV) clone 4-1 ( 4-1) similar to sequences of CKS-17 on the induction of systemic lupus erythematosus (SLE)-related immune abnormalities. Our results indicated that this peptide could induce T-cell activation and anergy in normal peripheral blood mononuclear cells, and the peptide could also promote the production of interleukins IL-6 and IL-16. These phenomena are representative immune abnormalities observed in SLE patients. Thus, our findings support the possibility that HERV acts as a pathogen in human SLE. |
| Keywords: | Human endogenous retrovirus systemic lupus erythematosus Interleukin-16 T-cell activation T-cell anergy |
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