| 孕鼠维生素D缺乏对子鼠长骨维生素D受体蛋白表达的影响 |
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| 引用本文： | 吴 越,周晓玉,李婵娟.孕鼠维生素D缺乏对子鼠长骨维生素D受体蛋白表达的影响[J].南京医科大学学报,2009,29(3):361-363385. |
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| 作者姓名： | 吴 越 周晓玉 李婵娟 |
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| 作者单位： | 吴越,周晓玉,WU Yue,ZHOU Xiao-yu(南京医科大学附属南京儿童医院新生儿科,江苏,南京,210008);李婵娟,LI Chan-juan(南京医科大学附属南京妇幼保健院妇产科,江苏,南京,210004)
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| 基金项目： | 南京市医学科技发展一般性项目，南京医科大学科技发展基金重点项目 |
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| 摘 要： | 目的:研究大鼠孕期维生素D(VitD)缺乏对其子鼠长骨中维生索D受体(VDR)蛋白表达的影响.方法:成熟雌性SD大鼠36只随机分为模型组和对照组各18只,模型组以不含VitD的大鼠饲料避光喂养,对照组以标准饲料正常光照喂养.2周后与成熟SD雄性大鼠交配,分别取孕20天(E20d)、生后1天(B1d)和生后7天(B7d)子鼠左侧股骨.用Western blotting方法检测子鼠股骨VDR蛋白水平的表达.结果:VDR蛋白在E20d、B1d和B7d子鼠股骨的表达量,模型组均显著低于对照组(P均<0.05).结论:孕鼠VitD缺乏可下调子鼠长骨VDR蛋白表达水平,可能为子鼠骨骼发育不良机制之一.
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| 关 键 词： | 维生素D缺乏 股骨 子鼠 维生素D受体 |
| 收稿时间： | 2008/8/19 0:00:00 |
Effects of vitamin D deficiency during pregnancy on femoral VDR protein expression of offspring |
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| WU Yue,ZHOU Xiao-yu and LI Chan-juan.Effects of vitamin D deficiency during pregnancy on femoral VDR protein expression of offspring[J].Acta Universitatis Medicinalis Nanjing,2009,29(3):361-363385. |
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| Authors: | WU Yue ZHOU Xiao-yu and LI Chan-juan |
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| Institution: | WU Yue,ZHOU Xiao-yu,LI Chan-juan1 |
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| Abstract: | Objective:To study the expression of VDR protein in the femurs of offsprings whose mothers were deficient of vitamin D. Methods:Thirty-six adult female SD rats were chosen and divided randomly into the control group(18 rats) and model group(18 rats). The control group was received vitamin D fodder with normal solarization and the model group received non-vitamin D fodder without solarization for 2 weeks. Then the female rats in two groups copulated with the male normal rats. The left femurs were collected f... |
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| Keywords: | Vitamin D deficiency femur offspring VDR |
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