Involvement of protein synthesis in the reconsolidation of memory at different time points after formation of conditioned reflex freezing in mice |
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Authors: | E. V. Murav’eva K. V. Anokhin |
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Affiliation: | (1) P. K. Anokhin Research Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow |
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Abstract: | The aim of the present work was to study the involvement of protein synthesis in the reconsolidation of memory at different periods of time after training. In mice trained in a conditioned reflex freezing model, memory was reactivated by a reminder combined with administration of the protein synthesis inhibitor cycloheximide. The results showed that suppression of protein synthesis on reactivation of memory 3, 6, and 24 h and 14 and 30 days after training impaired acquired conditioned reflex freezing. These data provide evidence that memories retrieved by a reminder require protein-dependent reorganization at both short (3–6 h) and long (14–30 days) periods after training. __________ Translated from Zhurnal Vysshei Nervnoi Deyatel’nosti imeni I. P. Pavlova, Vol. 56, No. 2, pp. 274–281, March–April, 2006. |
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Keywords: | memory reminder protein synthesis cycloheximide conditioned reflex freezing mice |
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